Target detail
REN
renin
Data: Live structured evidence (Supabase)
Foundation row from public.targets — full Open Targets / ChEMBL preload remains a future operator job (Phase 8H+).
Display name: renin
Aliases: REN, renin
Type / organism: protein_coding · Homo sapiens
Source: opentargets · ENSG00000143839
Index freshness: last_synced_at 2026-05-15T18:27:08.918+00:00 · updated 2026-05-15T18:27:09.31047+00:00
Limitations & build flags
- Read-only structured navigator
- No clinical outcome benefit inferred
- Trial presence does not imply success
- Drug identity may require normalization
- Terminated/withdrawn trials must remain visible
This symbol is listed in public.targets (operator seed or future preload). Connector-backed sections below may still show empty states until ChEMBL / Open Targets / ClinicalTrials.gov mirror rows exist for this marker.
Connectors represented in loaded rows for REN. Empty groups mean no matching rows — not a claim about biology or clinical use.
- ClinicalTrials.govLive when indexed
Registry mirror rows in clinical_trials when operators run the CT.gov enrichment CLI — browser never calls the registry directly.
- Open TargetsLive when indexed
Disease–target evidence rows when operators run enrich:opentargets (GraphQL from trusted scripts only).
Rows from disease_target_evidence for this symbol.
glioblastoma
literature · opentargets
Drug records tied via drug_targets — mechanistic linkage only.
No linked drug rows
When drug_targets and drugs rows exist for this symbol, they are listed here.
disease_drug_evidence rows on linked drugs whose evidence_type suggests approved-elsewhere discussion context.
No matching rows
Import repoDB-compatible disease–drug evidence or add structured rows to surface discussion candidates here.
Mirror rows whose text fields mention this symbol — registry context only.
NCT01721577 — Phase I/II Trial of AXL1717 in the Treatment of Recurrent Malignant Astrocytomas
Status: TERMINATED · clinicaltrials.gov
Open trials hubNCT02669173 — Capecitabine + Bevacizumab in Patients With Recurrent Glioblastoma
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT05053880 — A Study to Evaluate Safety and Efficacy of ACT001 and Anti-PD-1 in Patients With Surgically Accessible Recurrent Glioblastoma Multiforme
Status: UNKNOWN · clinicaltrials.gov
Open trials hubNCT03660761 — Apatinib in Recurrent or Refractory Intracranial Central Nervous System Malignant Tumors
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT00979862 — Cediranib Maleate and Cilengitide in Treating Patients With Progressive or Recurrent Glioblastoma
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT00761280 — Efficacy and Safety of AP 12009 in Patients With Recurrent or Refractory Anaplastic Astrocytoma or Secondary Glioblastoma
Status: TERMINATED · clinicaltrials.gov
Open trials hubNCT00293423 — GP96 Heat Shock Protein-Peptide Complex Vaccine in Treating Patients With Recurrent or Progressive Glioma
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT00813943 — Cilengitide, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma and Unmethylated Gene Promoter Status
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT02223052 — Bioequivalence & Food Effect Study in Patients With Solid Tumor or Hematologic Malignancies
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT06831526 — Neoadjuvant Chemoradiotherapy With or Without Concurrent Azeliragon in Patients With Newly Diagnosed Glioblastoma
Status: RECRUITING · clinicaltrials.gov
Open trials hubNCT04051606 — Regorafenib in Bevacizumab Refractory Recurrent Glioblastoma
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT01582269 — A Study in Recurrent Glioblastoma (GB)
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT05909618 — Crizanlizumab Alone or in Combination With Nivolumab for Glioblastoma and Melanoma With Brain Metastases
Status: RECRUITING · clinicaltrials.gov
Open trials hubNCT00797940 — Convection Enhanced Localized Administration of PRX321 With Real-time Imaging for Therapy of Recurrent Glioblastoma (CLARITY-1)
Status: WITHDRAWN · clinicaltrials.gov
Open trials hubNCT01124240 — Temozolomide and Procarbazine With Cilengitide for Patients With Glioblastoma Multiforme Without Methylation of the MGMT Promoter Gene
Status: UNKNOWN · clinicaltrials.gov
Open trials hubNCT03034135 — Safety, Tolerability and Efficacy of Disulfiram and Copper Gluconate in Recurrent Glioblastoma
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT03115333 — DSC-MRI in Measuring rCBV for Early Response to Bevacizumab in Patients With Recurrent Glioblastoma
Status: ACTIVE_NOT_RECRUITING · clinicaltrials.gov
Open trials hubNCT00006358 — Temozolomide Plus Thalidomide in Treating Patients With Recurrent or Progressive Brain Tumor
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT01631552 — Study of Sacituzumab Govitecan-hziy (IMMU-132) in Adults With Epithelial Cancer
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT00387933 — Imatinib Mesylate, Vatalanib, and Hydroxyurea in Treating Patients With Recurrent or Relapsed Malignant Glioma
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT01849146 — Adavosertib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT02698280 — Bevacizumab and Nimustine in Patients With Recurrent High Grade Glioma
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT00104091 — Safety and Efficacy Study to Treat Recurrent Grade 4 Malignant Brain Tumors
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT00704080 — A Study of XL765 (SAR245409) in Combination With Temozolomide With and Without Radiation in Adults With Malignant Gliomas
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT03107780 — Testing the Ability of AMG 232 (KRT 232) to Get Into the Tumor in Patients With Brain Cancer
Status: TERMINATED · clinicaltrials.gov
Open trials hubNCT03626896 — Safety of BBB Disruption Using NaviFUS System in Recurrent Glioblastoma Multiforme (GBM) Patients
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT03033524 — Trial to Evaluate the Safety of TTAC-0001(Tanibirumab) in Recurrent Glioblastoma
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT00433381 — Bevacizumab and Irinotecan or Temozolomide in Treating Patients With Recurrent or Refractory Glioblastoma Multiforme or Gliosarcoma
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT02433392 — Study of Intraparenchymal Therapy as Adjunct Therapy in Patients With Recurrent, Resectable Glioblastoma Multiforme.
Status: TERMINATED · clinicaltrials.gov
Open trials hubNCT06672575 — A Phase I/II Study of IVONESCIMAB in Recurrent Glioblastoma
Status: RECRUITING · clinicaltrials.gov
Open trials hubNCT00071539 — Safety and Efficacy Study to Treat Recurrent Grade 4 Malignant Brain Tumors
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT01011231 — Study of Gamma-Knife Radiosurgery Using Magnetic Resonance Imaging (MRI) Spectroscopy for Recurrent Glioma
Status: TERMINATED · clinicaltrials.gov
Open trials hubNCT03705351 — Tumor Treating Fields With Chemoradiation in Newly Diagnosed GBM
Status: TERMINATED · clinicaltrials.gov
Open trials hubNCT01499251 — Clinical Study on the Safety and Tolerability of Macitentan in Combination With Dose-dense Temozolomide in Patients With Recurrent Glioblastoma
Status: TERMINATED · clinicaltrials.gov
Open trials hubNCT00584883 — A Phase I Study of ABT 510 for Newly Diagnosed Glioblastoma Multiforme
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT01985256 — Study of a Retroviral Replicating Vector Given Intravenously to Patients Undergoing Surgery for Recurrent Brain Tumor
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT06072586 — A Phase 0/1 Study of BDTX-1535 in Recurrent High-Grade Glioma (rHGG) and Newly Diagnosed Glioblastoma (nGBM) Participants With EGFR Alterations or Fusions
Status: RECRUITING · clinicaltrials.gov
Open trials hubNCT00509431 — Erlotinib and Sirolimus in Treating Patients With Recurrent Malignant Glioma
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT04671459 — TTFields and Radiosurgery of Recurrent Glioblastoma +/- 18F-Fluoro-Ethyl-Thyrosine
Status: UNKNOWN · clinicaltrials.gov
Open trials hubNCT01865162 — Ketogenic Diet as Adjunctive Treatment in Refractory/End-stage Glioblastoma Multiforme: a Pilot Study
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT02661282 — Autologous CMV-Specific Cytotoxic T Cells and Temozolomide in Treating Patients With Glioblastoma
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT01925573 — Optune(NOVOTTF-100A)+ Bevacizumab+ Hypofractionated Stereotactic Irradiation Bevacizumab-Naive Recurrent Glioblastoma (GCC 1344)
Status: TERMINATED · clinicaltrials.gov
Open trials hubNCT03596086 — HSV-tk + Valacyclovir + SBRT + Chemotherapy for Recurrent GBM
Status: RECRUITING · clinicaltrials.gov
Open trials hubNCT00006246 — Busulfan in Treating Children and Adolescents With Refractory CNS Cancer
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT00979173 — Pharmacokinetics (PK) Study of AC480 for Recurrent Glioma
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT02800486 — Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA
Status: RECRUITING · clinicaltrials.gov
Open trials hubNCT04221503 — Niraparib/TTFields in GBM
Status: ACTIVE_NOT_RECRUITING · clinicaltrials.gov
Open trials hubNCT03463265 — Nab-sirolimus in Recurrent High Grade Glioma and Newly Diagnosed Glioblastoma
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT00727506 — BIBW 2992 (Afatinib) With or Without Daily Temozolomide in the Treatment of Patients With Recurrent Malignant Glioma
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT02394665 — Dose Escalated MRSI Guided Radiation Therapy in Glioblastoma
Status: TERMINATED · clinicaltrials.gov
Open trials hubNCT01062399 — Everolimus, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT04547621 — HSRT and IMRT Chemoradiotherapy for Newly Diagnosed GBM
Status: UNKNOWN · clinicaltrials.gov
Open trials hubNCT07138001 — Phase 2 Clinical Trial of KH617
Status: NOT_YET_RECRUITING · clinicaltrials.gov
Open trials hubNCT00752323 — Imaging Procedure Using ALA in Finding Residual Tumor in Grade IV Malignant Astrocytoma
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT02815410 — Validation of the Role of Levetiracetam for Newly Diagnosed GBM Patients
Status: UNKNOWN · clinicaltrials.gov
Open trials hubNCT04863950 — Investigator-Initiated Study of Imipramine Hydrochloride and Lomustine in Recurrent Glioblastoma
Status: RECRUITING · clinicaltrials.gov
Open trials hubNCT04600817 — A Study to Evaluate the Efficacy and Safety of TJ107 in Lympopenic Patients With Newly Diagnosed Glioblastoma Who Completed Standard Concurrent Chemoradiotherapy (CCRT)
Status: UNKNOWN · clinicaltrials.gov
Open trials hubNCT05765812 — A Study of Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma
Status: RECRUITING · clinicaltrials.gov
Open trials hubNCT00036894 — CC-5013 in Treating Patients With Recurrent Glioma
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT02678975 — Disulfiram in Recurrent Glioblastoma
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT04547855 — Anlotinib Combined With Dose-dense Temozolomide for the First Recurrent or Progressive Glioblastoma After STUPP Regimen
Status: UNKNOWN · clinicaltrials.gov
Open trials hubNCT05708352 — A Phase 2 Study of the Ketogenic Diet vs Standard Anti-cancer Diet Guidance for Patients With Glioblastoma in Combination With Standard-of-care Treatment
Status: RECRUITING · clinicaltrials.gov
Open trials hubNCT04656535 — AB154 Combined With AB122 for Recurrent Glioblastoma
Status: ACTIVE_NOT_RECRUITING · clinicaltrials.gov
Open trials hubNCT06558214 — OPTIMUS PRIME: Safety and Feasibility of OPTune GIO® Integrated With MRI-gUided Laser Ablation Surgery and Pembrolizumab for Recurrent GlIoblastoMa, A randomizEd Trial
Status: RECRUITING · clinicaltrials.gov
Open trials hubNCT04440358 — Exablate Blood-Brain Barrier Disruption With Carboplatin for the Treatment of rGBM
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT01478178 — Safety Study of VAL-083 in Patients With Recurrent Malignant Glioma
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT07485049 — BGB-58067 in Newly Diagnosed Glioblastoma Patients With MTAP-Deleted Tumors
Status: RECRUITING · clinicaltrials.gov
Open trials hubNCT04143425 — Response Prediction for Anti-angiogenic Treatment in Recurrent Glioblastoma
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT01989884 — An Efficacy Study Of Ortataxel In Recurrent Glioblastoma
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT00800917 — A Study of Temsirolimus and Bevacizumab in Recurrent Glioblastoma Multiforme
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT03687034 — A Study of the Safety and Pharmacokinetics of BRCX014 in Patients With Glioblastoma
Status: UNKNOWN · clinicaltrials.gov
Open trials hubNCT03618667 — GC1118 in Recurrent Glioblastoma Patients With High EGFR Amplification
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT04854044 — ONC201 and Radiation Therapy Before Surgery for the Treatment of Recurrent Glioblastoma
Status: WITHDRAWN · clinicaltrials.gov
Open trials hubNCT07521657 — Efficacy of Mirdametinib Alone or Combination With Radiotherapy for Germline and Sporadic NF1-Altered High-Grade Glioma
Status: NOT_YET_RECRUITING · clinicaltrials.gov
Open trials hubNCT02658981 — Anti-LAG-3 Alone & in Combination w/ Nivolumab Treating Patients w/ Recurrent GBM (Anti-CD137 Arm Closed 10/16/18)
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT04590664 — Verteporfin for the Treatment of Recurrent High Grade EGFR-Mutated Glioblastoma
Status: RECRUITING · clinicaltrials.gov
Open trials hubNCT04222309 — Laparoscopically Harvested Omental Free Tissue Autograft to Bypass the Blood Brain Barrier (BBB) in Human Recurrent Glioblastoma Multiforme (rGBM)
Status: SUSPENDED · clinicaltrials.gov
Open trials hubNCT02253212 — Safety of BBB Opening With the SonoCloud
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT04846257 — Specific Preoperative Dynamic Contrast-enhanced MRI Semi-quantitative Markers Can Correlate With Vascularity in Specific Areas of the Glioblastoma Tissue and Predict Recurrence
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT05241392 — Safety and Efficacy Study of Anti-B7-H3 CAR-T Cell Therapy for Recurrent Glioblastoma
Status: ACTIVE_NOT_RECRUITING · clinicaltrials.gov
Open trials hubNCT00609999 — Ph I Dasatinib + Erlotinib in Recurrent MG
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT00562419 — CT-322 in Treating Patients With Recurrent Glioblastoma Multiforme and Combination Therapy With Irinotecan
Status: UNKNOWN · clinicaltrials.gov
Open trials hubNCT03275558 — Clinical Trial of the Use of the Nasal Spray of Patients With Recurrence of Glioblastoma
Status: WITHDRAWN · clinicaltrials.gov
Open trials hubNCT03466450 — Glasdegib (PF-04449913) With Temozolomide Newly Diagnosed Glioblastoma
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT04541225 — Study of NUV-422 in Adults With Recurrent or Refractory High-grade Gliomas and Solid Tumors
Status: TERMINATED · clinicaltrials.gov
Open trials hubNCT00823797 — Bendamustine Hydrochloride in Treating Patients With Recurrent or Progressive Anaplastic Glioma
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT02717962 — Study of VAL-083 in Patients With MGMT Unmethylated, Bevacizumab-naive Glioblastoma in the Adjuvant or Recurrent Setting
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT01782976 — Ph II Cilengitide Plus Bevacizumab for Recurrent Glioblastoma (GBM)
Status: WITHDRAWN · clinicaltrials.gov
Open trials hubNCT00004024 — Biological Therapy Following Surgery and Radiation Therapy in Treating Patients With Primary or Recurrent Astrocytoma or Oligodendroglioma
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT00895180 — Ramucirumab or Anti-PDGFR Alpha Monoclonal Antibody IMC-3G3 in Treating Patients With Recurrent Glioblastoma Multiforme
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT05879120 — Randomized Study of Neo-adjuvant and Adjuvant Pembrolizumab With and Without Targeted Blood Brain Barrier Opening Using Exablate MRI-guided Focused Ultrasound (Exablate MRgFUS) for Recurrent Glioblastoma
Status: WITHDRAWN · clinicaltrials.gov
Open trials hubNCT00939991 — Suberoylanilide Hydroxamic Acid (SAHA), Bevacizumab, Daily Temozolomide for Recurrent Malignant Gliomas
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT04991870 — Phase I CB-NK-TGF-ßR2-/NR3C1- in rGBM
Status: RECRUITING · clinicaltrials.gov
Open trials hubNCT00305656 — AZD2171 in Treating Patients With Recurrent Glioblastoma Multiforme
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT02444546 — Wild-Type Reovirus in Combination With Sargramostim in Treating Younger Patients With High-Grade Relapsed or Refractory Brain Tumors
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT06359379 — Ropidoxuridine as a Radiosensitizer in Newly Diagnosed IDH-Wildtype Glioblastoma With Unmethylated MGMT Promoter
Status: TERMINATED · clinicaltrials.gov
Open trials hubNCT04047303 — CNS Penetration, PK and PD of Preoperative CC-90010 in Progressive/Recurrent Diffuse Astrocytoma, Anaplastic Astrocytoma and Glioblastoma
Status: TERMINATED · clinicaltrials.gov
Open trials hubNCT04908176 — A Drug-drug Interaction Study of Avapritinib and Midazolam
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT00095940 — Lapatinib in Treating Young Patients With Recurrent or Refractory Central Nervous System Tumors
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT03152318 — A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2
Status: ACTIVE_NOT_RECRUITING · clinicaltrials.gov
Open trials hubNCT04536649 — Proton and Heavy Ion Beam Radiation vs. Photon Beam Radiation for Newly Diagnosed Glioblastoma.
Status: UNKNOWN · clinicaltrials.gov
Open trials hubNCT01870726 — Safety and Efficacy of INC280 and Buparlisib (BKM120) in Patients With Recurrent Glioblastoma
Status: TERMINATED · clinicaltrials.gov
Open trials hubNCT02575027 — Palliative 4pi Radiotherapy in Treating Patients With Recurrent Glioblastoma Multiforme
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT01342757 — Magnetic Resonance Spectroscopy Imaging in Predicting Response to Vorinostat and Temozolomide in Patients With Recurrent or Progressive Glioblastoma
Status: COMPLETED · clinicaltrials.gov
Open trials hubNCT03970447 — A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma
Status: RECRUITING · clinicaltrials.gov
Open trials hubNCT02974621 — Cediranib Maleate and Olaparib Compared to Bevacizumab in Treating Patients With Recurrent Glioblastoma
Status: ACTIVE_NOT_RECRUITING · clinicaltrials.gov
Open trials hubNCT06501911 — A Study of Bicalutamide With Brain Re-irradiation to Treat Recurrent/Progressive High Grade Glioma
Status: WITHDRAWN · clinicaltrials.gov
Open trials hubNCT05557292 — RMC-5552 Monotherapy in Adult Subjects With Recurrent Glioblastoma
Status: TERMINATED · clinicaltrials.gov
Open trials hubNCT06499831 — 18F-FET-PET/MRI vs Standard MRI Alone for Stereotactic RadioTherapy Planning for High Grade Brain Gliomas
Status: ACTIVE_NOT_RECRUITING · clinicaltrials.gov
Open trials hubNCT06264388 — DB107-Retroviral Replicating Vector (RRV) Combined With DB107-Flucytosine (FC) in Patients With Recurrent Glioblastoma or Anaplastic Astrocytoma
Status: RECRUITING · clinicaltrials.gov
Open trials hubNCT00499473 — Sunitinib in Treating Patients With Recurrent Malignant Gliomas
Status: COMPLETED · clinicaltrials.gov
Open trials hubRepurposing signal rows for drugs linked to this target via drug_targets.
No research signals for linked drugs
Run the deterministic signal builder after drug_targets and source rows are present.
Structured rows with negative evidence_direction on disease–drug or signal tables.
No negative-direction rows
When structured evidence includes explicit negative direction fields, they surface here for oncology review.
- clinicaltrials.gov: 113
- opentargets: 1
Structured evidence rows link this marker to cohort contexts when ingested — interpret as research context only.
Disease contexts
0
Linked drugs
0
Linked in dataset
0
Research signals
0
Doctor-discussion candidate and related tags are descriptive only.
Signals list: Live structured evidence (Supabase)
No matching live evidence found
When repurposing_signal rows reference this marker via linked drugs, summaries appear here.