Target detail

PTEN

phosphatase and tensin homolog

Data: Live structured evidence (Supabase)

Marker index metadata

Foundation row from public.targets — full Open Targets / ChEMBL preload remains a future operator job (Phase 8H+).

Display name: phosphatase and tensin homolog

Aliases: PTEN, phosphatase and tensin homolog

Type / organism: protein_coding · Homo sapiens

Source: opentargets · ENSG00000171862

Index freshness: last_synced_at 2026-05-15T19:09:44.908+00:00 · updated 2026-05-15T19:09:45.335259+00:00

Disease hub (glioblastoma)Guided · PTEN

Limitations & build flags

Read-only structured navigator
No clinical outcome benefit inferred
Trial presence does not imply success
Drug identity may require normalization
Terminated/withdrawn trials must remain visible

Target index (foundation)

This symbol is listed in public.targets (operator seed or future preload). Connector-backed sections below may still show empty states until ChEMBL / Open Targets / ClinicalTrials.gov mirror rows exist for this marker.

Glioblastoma disease hub·Guided lookup

Live structured evidence · sources

Connectors represented in loaded rows for PTEN. Empty groups mean no matching rows — not a claim about biology or clinical use.

ClinicalTrials.govLive when indexed
Registry mirror rows in clinical_trials when operators run the CT.gov enrichment CLI — browser never calls the registry directly.
Open TargetsLive when indexed
Disease–target evidence rows when operators run enrich:opentargets (GraphQL from trusted scripts only).

Open Targets · disease–target evidence

Rows from disease_target_evidence for this symbol.

glioblastoma

literature · opentargets

ChEMBL · linked drugs (drug_targets)

Drug records tied via drug_targets — mechanistic linkage only.

No linked drug rows

When drug_targets and drugs rows exist for this symbol, they are listed here.

repoDB-style · approved-elsewhere discussion candidates

disease_drug_evidence rows on linked drugs whose evidence_type suggests approved-elsewhere discussion context.

No matching rows

Import repoDB-compatible disease–drug evidence or add structured rows to surface discussion candidates here.

ClinicalTrials.gov · trial-matched options

Mirror rows whose text fields mention this symbol — registry context only.

NCT01870726 — Safety and Efficacy of INC280 and Buparlisib (BKM120) in Patients With Recurrent Glioblastoma

Status: TERMINATED · clinicaltrials.gov

Open trials hub

CANTI signal builder · target-linked research signals

Repurposing signal rows for drugs linked to this target via drug_targets.

No research signals for linked drugs

Run the deterministic signal builder after drug_targets and source rows are present.

Caution / negative-evidence rows

Structured rows with negative evidence_direction on disease–drug or signal tables.

No negative-direction rows

When structured evidence includes explicit negative direction fields, they surface here for oncology review.

Missing evidence · row counts by source string

opentargets: 1
clinicaltrials.gov: 1

Summary row (aggregated list)

Structured evidence rows link this marker to cohort contexts when ingested — interpret as research context only.

Disease contexts

Linked drugs

Linked in dataset

Research signals

Evidence badges (illustrative)

Doctor-discussion candidate and related tags are descriptive only.

Appears in source landscapeLinked in datasetRequires oncology review

Linked research signals (list read)

Signals list: Live structured evidence (Supabase)

No matching live evidence found

When repurposing_signal rows reference this marker via linked drugs, summaries appear here.