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Target detail

MARK1

microtubule affinity regulating kinase 1

Data: Live structured evidence (Supabase)

Marker index metadata

Foundation row from public.targets — full Open Targets / ChEMBL preload remains a future operator job (Phase 8H+).

Display name: microtubule affinity regulating kinase 1

Aliases: MARK1, microtubule affinity regulating kinase 1

Type / organism: protein_coding · Homo sapiens

Source: opentargets · ENSG00000116141

Index freshness: last_synced_at 2026-05-15T19:23:31.792+00:00 · updated 2026-05-15T19:23:32.32399+00:00

Disease hub (glioblastoma)Guided · MARK1

Limitations & build flags

  • Read-only structured navigator
  • No clinical outcome benefit inferred
  • Trial presence does not imply success
  • Drug identity may require normalization
  • Terminated/withdrawn trials must remain visible
Target index (foundation)

This symbol is listed in public.targets (operator seed or future preload). Connector-backed sections below may still show empty states until ChEMBL / Open Targets / ClinicalTrials.gov mirror rows exist for this marker.

Glioblastoma disease hub·Guided lookup
Live structured evidence · sources

Connectors represented in loaded rows for MARK1. Empty groups mean no matching rows — not a claim about biology or clinical use.

  • Power BI landscapeLive when indexed

    Structured imports from operator CSV / Power BI flows when configured — appears in live rows when present.

  • Open TargetsLive when indexed

    Disease–target evidence rows when operators run enrich:opentargets (GraphQL from trusted scripts only).

Open Targets · disease–target evidence

Rows from disease_target_evidence for this symbol.

Solid tumor research cohort (dev)

marker_context · dev_seed

ChEMBL · linked drugs (drug_targets)

Drug records tied via drug_targets — mechanistic linkage only.

HKB-1 (dev slice)

hypothetical kinase binder hkb-1

Open drug
repoDB-style · approved-elsewhere discussion candidates

disease_drug_evidence rows on linked drugs whose evidence_type suggests approved-elsewhere discussion context.

No matching rows

Import repoDB-compatible disease–drug evidence or add structured rows to surface discussion candidates here.

ClinicalTrials.gov · trial-matched options

Mirror rows whose text fields mention this symbol — registry context only.

No matching live evidence found

Populate clinical_trials via the registry enrichment flow; this panel matches the symbol token in titles, conditions, or interventions.

CANTI signal builder · target-linked research signals

Repurposing signal rows for drugs linked to this target via drug_targets.

No research signals for linked drugs

Run the deterministic signal builder after drug_targets and source rows are present.

Caution / negative-evidence rows

Structured rows with negative evidence_direction on disease–drug or signal tables.

No negative-direction rows

When structured evidence includes explicit negative direction fields, they surface here for oncology review.

Missing evidence · row counts by source string

No ClinicalTrials.gov mirror rows mention this symbol in titles, conditions, or interventions (within the loaded window).

  • dev_seed: 3
Summary row (aggregated list)

Structured evidence rows link this marker to cohort contexts when ingested — interpret as research context only.

Disease contexts

0

Linked drugs

0

Linked in dataset

0

Research signals

0

Evidence badges (illustrative)

Doctor-discussion candidate and related tags are descriptive only.

Appears in source landscapeLinked in datasetRequires oncology review
Linked research signals (list read)

Signals list: Live structured evidence (Supabase)

No matching live evidence found

When repurposing_signal rows reference this marker via linked drugs, summaries appear here.