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Target detail

DNA

DNA (research marker)

Data: Live structured evidence (Supabase)

Limitations & build flags

  • Read-only structured navigator
  • No clinical outcome benefit inferred
  • Trial presence does not imply success
  • Drug identity may require normalization
  • Terminated/withdrawn trials must remain visible
Live structured evidence · sources

Connectors represented in loaded rows for DNA. Empty groups mean no matching rows — not a claim about biology or clinical use.

  • Power BI landscapeLive when indexed

    Structured imports from operator CSV / Power BI flows when configured — appears in live rows when present.

  • ChEMBLLive when indexed

    Drug–target and related enrichment rows when operators run enrich:chembl (server/CLI only).

  • repoDBLive when indexed

    Disease–drug style rows in disease_drug_evidence when operators import repoDB-compatible files via CLI.

  • CANTI signal builderLive when indexed

    Deterministic repurposing-signal rows produced by the in-repo signal builder when operators run the build pipeline.

Open Targets · disease–target evidence

Rows from disease_target_evidence for this symbol.

No matching live evidence found

Ingest Open Targets disease–target rows for this symbol to populate this section.

ChEMBL · linked drugs (drug_targets)

Drug records tied via drug_targets — mechanistic linkage only.

Temozolomide

temozolomide

Open drug
repoDB-style · approved-elsewhere discussion candidates

disease_drug_evidence rows on linked drugs whose evidence_type suggests approved-elsewhere discussion context.

No matching rows

Import repoDB-compatible disease–drug evidence or add structured rows to surface discussion candidates here.

ClinicalTrials.gov · trial-matched options

Mirror rows whose text fields mention this symbol — registry context only.

No matching live evidence found

Populate clinical_trials via the registry enrichment flow; this panel matches the symbol token in titles, conditions, or interventions.

CANTI signal builder · target-linked research signals

Repurposing signal rows for drugs linked to this target via drug_targets.

Repurposing research signal · Temozolomide · v0.1

Deterministic research signal for Temozolomide. Aggregate template score 40 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, clinicaltrials.gov, repodb. Negative or caution-bearing registry/repoDB context is present — read components in raw_json. Missing relative to the Phase 8A template: Open Targets disease–target evidence. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

Open signals hub
Caution / negative-evidence rows

Structured rows with negative evidence_direction on disease–drug or signal tables.

a997de09-cc75-400a-abe6-379355586d37 — cutaneous melanoma

repodb_disease_drug_context

a997de09-cc75-400a-abe6-379355586d37 — lung cancer

repodb_disease_drug_context

a997de09-cc75-400a-abe6-379355586d37 — gliosarcoma

repodb_disease_drug_context

a997de09-cc75-400a-abe6-379355586d37 — glioblastoma

repodb_disease_drug_context

a997de09-cc75-400a-abe6-379355586d37 — astrocytoma

repodb_disease_drug_context

a997de09-cc75-400a-abe6-379355586d37 — oligoastrocytoma

repodb_disease_drug_context

a997de09-cc75-400a-abe6-379355586d37 — cutaneous melanoma

repodb_disease_drug_context

a997de09-cc75-400a-abe6-379355586d37 — adenocarcinoma

repodb_disease_drug_context

a997de09-cc75-400a-abe6-379355586d37 — large cell carcinoma

repodb_disease_drug_context

a997de09-cc75-400a-abe6-379355586d37 — glioblastoma

repodb_disease_drug_context

a997de09-cc75-400a-abe6-379355586d37 — oligoastrocytoma

repodb_disease_drug_context

a997de09-cc75-400a-abe6-379355586d37 — glioblastoma

repodb_disease_drug_context

a997de09-cc75-400a-abe6-379355586d37 — central nervous system disease

repodb_disease_drug_context

a997de09-cc75-400a-abe6-379355586d37 — kidney neoplasm

repodb_disease_drug_context

a997de09-cc75-400a-abe6-379355586d37 — neuroblastoma

repodb_disease_drug_context

a997de09-cc75-400a-abe6-379355586d37 — Ewing sarcoma

repodb_disease_drug_context

a997de09-cc75-400a-abe6-379355586d37 — malignant glioma

repodb_disease_drug_context

a997de09-cc75-400a-abe6-379355586d37 — neuroblastoma

repodb_disease_drug_context

a997de09-cc75-400a-abe6-379355586d37 — melanoma

repodb_disease_drug_context

a997de09-cc75-400a-abe6-379355586d37 — gliosarcoma

repodb_disease_drug_context

a997de09-cc75-400a-abe6-379355586d37 — glioblastoma

repodb_disease_drug_context

Missing evidence · row counts by source string

No ClinicalTrials.gov mirror rows mention this symbol in titles, conditions, or interventions (within the loaded window).

  • clinicaltrials.gov: 109
  • repodb: 24
  • chembl: 1
  • canti_signal_builder: 1
Summary row (aggregated list)

Structured evidence rows link this marker to cohort contexts when ingested — interpret as research context only.

Disease contexts

0

Linked drugs

0

Linked in dataset

0

Research signals

0

Evidence badges (illustrative)

Doctor-discussion candidate and related tags are descriptive only.

Appears in source landscapeLinked in datasetRequires oncology review
Linked research signals (list read)

Signals list: Live structured evidence (Supabase)

Repurposing research signal · Temozolomide · v0.1

Deterministic research signal for Temozolomide. Aggregate template score 40 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, clinicaltrials.gov, repodb. Negative or caution-bearing registry/repoDB context is present — read components in raw_json. Missing relative to the Phase 8A template: Open Targets disease–target evidence. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

View signals hub