Target detail
BRAF
B-Raf proto-oncogene, serine/threonine kinase
Data: Live structured evidence (Supabase)
Foundation row from public.targets — full Open Targets / ChEMBL preload remains a future operator job (Phase 8H+).
Display name: B-Raf proto-oncogene, serine/threonine kinase
Aliases: BRAF, B-Raf proto-oncogene, serine/threonine kinase
Type / organism: protein_coding · Homo sapiens
Source: opentargets · ENSG00000157764
Index freshness: last_synced_at 2026-05-15T20:16:57.697+00:00 · updated 2026-05-15T20:16:58.224198+00:00
Limitations & build flags
- Read-only structured navigator
- No clinical outcome benefit inferred
- Trial presence does not imply success
- Drug identity may require normalization
- Terminated/withdrawn trials must remain visible
This symbol is listed in public.targets (operator seed or future preload). Connector-backed sections below may still show empty states until ChEMBL / Open Targets / ClinicalTrials.gov mirror rows exist for this marker.
Connectors represented in loaded rows for BRAF. Empty groups mean no matching rows — not a claim about biology or clinical use.
- Open TargetsLive when indexed
Disease–target evidence rows when operators run enrich:opentargets (GraphQL from trusted scripts only).
- ChEMBLLive when indexed
Drug–target and related enrichment rows when operators run enrich:chembl (server/CLI only).
- CANTI signal builderLive when indexed
Deterministic repurposing-signal rows produced by the in-repo signal builder when operators run the build pipeline.
Rows from disease_target_evidence for this symbol.
glioblastoma
affected_pathway,literature · opentargets
Drug records tied via drug_targets — mechanistic linkage only.
LGX-806
chembl3545263
CHEMBL524068
chembl524068
CHEMBL511337
chembl511337
CHEMBL471408
chembl471408
CHEMBL200320
chembl200320
CHEMBL516808
chembl516808
CHEMBL460344
chembl460344
CHEMBL478649
chembl478649
CHEMBL482576
chembl482576
RG-7256
chembl3545080
CHEMBL482926
chembl482926
CHEMBL248397
chembl248397
CHEMBL1964274
chembl1964274
CHEMBL516312
chembl516312
ENCORAFENIB
chembl3301612
REGORAFENIB
chembl1946170
CHEMBL459514
chembl459514
CHEMBL516644
chembl516644
CHEMBL404630
chembl404630
CHEMBL400109
chembl400109
CHEMBL526901
chembl526901
CHEMBL498113
chembl498113
SORAFENIB
chembl1336
CHEMBL480201
chembl480201
CHEMBL521155
chembl521155
CHEMBL496202
chembl496202
CHEMBL520330
chembl520330
CHEMBL521562
chembl521562
CHEMBL425576
chembl425576
CHEMBL489230
chembl489230
CHEMBL511661
chembl511661
CHEMBL521337
chembl521337
CHEMBL470591
chembl470591
CHEMBL454104
chembl454104
CHEMBL466397
chembl466397
CHEMBL518975
chembl518975
CHEMBL521305
chembl521305
CHEMBL511836
chembl511836
CHEMBL483916
chembl483916
CHEMBL501736
chembl501736
CHEMBL511119
chembl511119
CHEMBL524640
chembl524640
CHEMBL247619
chembl247619
CHEMBL198400
chembl198400
CHEMBL484317
chembl484317
CHEMBL498674
chembl498674
CHEMBL200172
chembl200172
CHEMBL1964275
chembl1964275
CHEMBL483717
chembl483717
CHEMBL486341
chembl486341
CHEMBL199605
chembl199605
CHEMBL450519
chembl450519
CHEMBL370112
chembl370112
CHEMBL373006
chembl373006
CHEMBL394826
chembl394826
CHEMBL1964267
chembl1964267
CHEMBL475433
chembl475433
CHEMBL398872
chembl398872
CHEMBL483297
chembl483297
CHEMBL482932
chembl482932
CHEMBL485246
chembl485246
CHEMBL496612
chembl496612
CHEMBL521725
chembl521725
CHEMBL509283
chembl509283
CHEMBL459935
chembl459935
CHEMBL498487
chembl498487
CHEMBL496203
chembl496203
CHEMBL518187
chembl518187
CHEMBL199833
chembl199833
CHEMBL400308
chembl400308
CHEMBL490841
chembl490841
CHEMBL500151
chembl500151
CHEMBL498524
chembl498524
LY-3009120
chembl3577124
CHEMBL498317
chembl498317
CHEMBL470808
chembl470808
CHEMBL440761
chembl440761
CHEMBL520623
chembl520623
CHEMBL200431
chembl200431
CHEMBL400057
chembl400057
CHEMBL247250
chembl247250
CHEMBL484106
chembl484106
CHEMBL483718
chembl483718
VEMURAFENIB
chembl1229517
CHEMBL520627
chembl520627
CHEMBL481681
chembl481681
CHEMBL524507
chembl524507
CHEMBL500142
chembl500142
CHEMBL483914
chembl483914
CHEMBL248257
chembl248257
CHEMBL498307
chembl498307
CHEMBL496479
chembl496479
ALTENUSIN
chembl483531
CHEMBL1964273
chembl1964273
CHEMBL523261
chembl523261
CHEMBL257167
chembl257167
CHEMBL504075
chembl504075
CHEMBL504135
chembl504135
CHEMBL501686
chembl501686
CHEMBL447317
chembl447317
CHEMBL483921
chembl483921
CHEMBL247618
chembl247618
CHEMBL200114
chembl200114
CHEMBL471415
chembl471415
CHEMBL200164
chembl200164
CHEMBL519976
chembl519976
CHEMBL485302
chembl485302
CHEMBL489229
chembl489229
CHEMBL462473
chembl462473
CHEMBL497670
chembl497670
DABRAFENIB MESYLATE
chembl2105729
CHEMBL247424
chembl247424
CHEMBL497701
chembl497701
CHEMBL523278
chembl523278
CHEMBL401710
chembl401710
CHEMBL201625
chembl201625
CHEMBL248226
chembl248226
CHEMBL199588
chembl199588
CHEMBL454028
chembl454028
CHEMBL496477
chembl496477
CHEMBL481563
chembl481563
CHEMBL480551
chembl480551
CHEMBL471407
chembl471407
CHEMBL201576
chembl201576
CHEMBL200637
chembl200637
CHEMBL470364
chembl470364
CHEMBL484968
chembl484968
CHEMBL477774
chembl477774
CHEMBL515491
chembl515491
CHEMBL482681
chembl482681
CHEMBL491055
chembl491055
CHEMBL501946
chembl501946
CHEMBL426476
chembl426476
CHEMBL471794
chembl471794
CHEMBL520818
chembl520818
CHEMBL459931
chembl459931
CHEMBL476066
chembl476066
CHEMBL521480
chembl521480
CHEMBL248860
chembl248860
CHEMBL489009
chembl489009
CHEMBL526268
chembl526268
CHEMBL482928
chembl482928
CHEMBL485300
chembl485300
CHEMBL487717
chembl487717
CHEMBL497700
chembl497700
CHEMBL519992
chembl519992
CHEMBL475795
chembl475795
CHEMBL482718
chembl482718
CHEMBL255497
chembl255497
CHEMBL486943
chembl486943
HESPERADIN
chembl514409
MALEIMIDE
chembl201511
TALAROFLAVONE
chembl408995
CHEMBL524812
chembl524812
CHEMBL475865
chembl475865
CHEMBL397345
chembl397345
CHEMBL525191
chembl525191
CHEMBL480200
chembl480200
CHEMBL86755
chembl86755
CHEMBL378600
chembl378600
CHEMBL408019
chembl408019
CHEMBL402424
chembl402424
CHEMBL200964
chembl200964
CHEMBL516655
chembl516655
CHEMBL498344
chembl498344
CHEMBL485299
chembl485299
CHEMBL484319
chembl484319
CHEMBL459714
chembl459714
CHEMBL489228
chembl489228
CHEMBL199355
chembl199355
CHEMBL498327
chembl498327
ALTERNARIENONIC ACID
chembl519395
CHEMBL500660
chembl500660
CHEMBL496409
chembl496409
CHEMBL460136
chembl460136
CHEMBL483709
chembl483709
CHEMBL484301
chembl484301
CHEMBL507714
chembl507714
CHEMBL430413
chembl430413
CHEMBL199281
chembl199281
CHEMBL514688
chembl514688
CHEMBL475794
chembl475794
CHEMBL489842
chembl489842
CHEMBL489823
chembl489823
CHEMBL498503
chembl498503
CHEMBL490454
chembl490454
CHEMBL477987
chembl477987
CHEMBL500416
chembl500416
CHEMBL503699
chembl503699
CHEMBL402029
chembl402029
CHEMBL198244
chembl198244
CHEMBL483525
chembl483525
CHEMBL246423
chembl246423
CHEMBL470799
chembl470799
CHEMBL480389
chembl480389
CHEMBL476859
chembl476859
CHEMBL371694
chembl371694
CHEMBL504906
chembl504906
CHEMBL427196
chembl427196
CHEMBL521731
chembl521731
disease_drug_evidence rows on linked drugs whose evidence_type suggests approved-elsewhere discussion context.
No matching rows
Import repoDB-compatible disease–drug evidence or add structured rows to surface discussion candidates here.
Mirror rows whose text fields mention this symbol — registry context only.
No matching live evidence found
Populate clinical_trials via the registry enrichment flow; this panel matches the symbol token in titles, conditions, or interventions.
Repurposing signal rows for drugs linked to this target via drug_targets.
Repurposing research signal · ALTENUSIN · v0.1
Deterministic research signal for ALTENUSIN. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
Open signals hubRepurposing research signal · CEP-32496 · v0.1
Deterministic research signal for CEP-32496. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
Open signals hubRepurposing research signal · ALTERNARIOL · v0.1
Deterministic research signal for ALTERNARIOL. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
Open signals hubRepurposing research signal · ALTERTOXIN I · v0.1
Deterministic research signal for ALTERTOXIN I. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
Open signals hubRepurposing research signal · ALTERNARIENONIC ACID · v0.1
Deterministic research signal for ALTERNARIENONIC ACID. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
Open signals hubRepurposing research signal · ARQ-736 · v0.1
Deterministic research signal for ARQ-736. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
Open signals hubRepurposing research signal · ALTERLACTONE · v0.1
Deterministic research signal for ALTERLACTONE. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
Open signals hubStructured rows with negative evidence_direction on disease–drug or signal tables.
No negative-direction rows
When structured evidence includes explicit negative direction fields, they surface here for oncology review.
No ClinicalTrials.gov mirror rows mention this symbol in titles, conditions, or interventions (within the loaded window).
- chembl: 500
- canti_signal_builder: 7
- opentargets: 1
Structured evidence rows link this marker to cohort contexts when ingested — interpret as research context only.
Disease contexts
0
Linked drugs
0
Linked in dataset
0
Research signals
0
Doctor-discussion candidate and related tags are descriptive only.
Signals list: Live structured evidence (Supabase)
Repurposing research signal · ALTERLACTONE · v0.1
Deterministic research signal for ALTERLACTONE. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hubRepurposing research signal · ALTERPORRIOL G/H · v0.1
Deterministic research signal for ALTERPORRIOL G/H. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hubRepurposing research signal · ALVOCIDIB · v0.1
Deterministic research signal for ALVOCIDIB. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hubRepurposing research signal · ARQ-736 · v0.1
Deterministic research signal for ARQ-736. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hubRepurposing research signal · ALTERNARIENONIC ACID · v0.1
Deterministic research signal for ALTERNARIENONIC ACID. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hubRepurposing research signal · ALTERTOXIN I · v0.1
Deterministic research signal for ALTERTOXIN I. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hubRepurposing research signal · ALTERSOLANOL A · v0.1
Deterministic research signal for ALTERSOLANOL A. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hubRepurposing research signal · ALTERNARIOL · v0.1
Deterministic research signal for ALTERNARIOL. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hubRepurposing research signal · CEP-32496 · v0.1
Deterministic research signal for CEP-32496. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hubRepurposing research signal · CANERTINIB · v0.1
Deterministic research signal for CANERTINIB. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hubRepurposing research signal · AST-487 · v0.1
Deterministic research signal for AST-487. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hubRepurposing research signal · BMS-387032 · v0.1
Deterministic research signal for BMS-387032. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hubRepurposing research signal · ALTENUSIN · v0.1
Deterministic research signal for ALTENUSIN. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hub