Back to targets

Target detail

BRAF

B-Raf proto-oncogene, serine/threonine kinase

Data: Live structured evidence (Supabase)

Marker index metadata

Foundation row from public.targets — full Open Targets / ChEMBL preload remains a future operator job (Phase 8H+).

Display name: B-Raf proto-oncogene, serine/threonine kinase

Aliases: BRAF, B-Raf proto-oncogene, serine/threonine kinase

Type / organism: protein_coding · Homo sapiens

Source: opentargets · ENSG00000157764

Index freshness: last_synced_at 2026-05-15T20:16:57.697+00:00 · updated 2026-05-15T20:16:58.224198+00:00

Limitations & build flags

  • Read-only structured navigator
  • No clinical outcome benefit inferred
  • Trial presence does not imply success
  • Drug identity may require normalization
  • Terminated/withdrawn trials must remain visible
Target index (foundation)

This symbol is listed in public.targets (operator seed or future preload). Connector-backed sections below may still show empty states until ChEMBL / Open Targets / ClinicalTrials.gov mirror rows exist for this marker.

Live structured evidence · sources

Connectors represented in loaded rows for BRAF. Empty groups mean no matching rows — not a claim about biology or clinical use.

  • Open TargetsLive when indexed

    Disease–target evidence rows when operators run enrich:opentargets (GraphQL from trusted scripts only).

  • ChEMBLLive when indexed

    Drug–target and related enrichment rows when operators run enrich:chembl (server/CLI only).

  • CANTI signal builderLive when indexed

    Deterministic repurposing-signal rows produced by the in-repo signal builder when operators run the build pipeline.

Open Targets · disease–target evidence

Rows from disease_target_evidence for this symbol.

glioblastoma

affected_pathway,literature · opentargets

ChEMBL · linked drugs (drug_targets)

Drug records tied via drug_targets — mechanistic linkage only.

LGX-806

chembl3545263

Open drug

CHEMBL524068

chembl524068

Open drug

CHEMBL511337

chembl511337

Open drug

CHEMBL471408

chembl471408

Open drug

CHEMBL200320

chembl200320

Open drug

CHEMBL516808

chembl516808

Open drug

CHEMBL460344

chembl460344

Open drug

CHEMBL478649

chembl478649

Open drug

CHEMBL482576

chembl482576

Open drug

RG-7256

chembl3545080

Open drug

CHEMBL482926

chembl482926

Open drug

CHEMBL248397

chembl248397

Open drug

CHEMBL1964274

chembl1964274

Open drug

CHEMBL516312

chembl516312

Open drug

ENCORAFENIB

chembl3301612

Open drug

REGORAFENIB

chembl1946170

Open drug

CHEMBL459514

chembl459514

Open drug

CHEMBL516644

chembl516644

Open drug

CHEMBL404630

chembl404630

Open drug

CHEMBL400109

chembl400109

Open drug

CHEMBL526901

chembl526901

Open drug

CHEMBL498113

chembl498113

Open drug

SORAFENIB

chembl1336

Open drug

CHEMBL480201

chembl480201

Open drug

CHEMBL521155

chembl521155

Open drug

CHEMBL496202

chembl496202

Open drug

CHEMBL520330

chembl520330

Open drug

CHEMBL521562

chembl521562

Open drug

CHEMBL425576

chembl425576

Open drug

CHEMBL489230

chembl489230

Open drug

CHEMBL511661

chembl511661

Open drug

CHEMBL521337

chembl521337

Open drug

CHEMBL470591

chembl470591

Open drug

CHEMBL454104

chembl454104

Open drug

CHEMBL466397

chembl466397

Open drug

CHEMBL518975

chembl518975

Open drug

CHEMBL521305

chembl521305

Open drug

CHEMBL511836

chembl511836

Open drug

CHEMBL483916

chembl483916

Open drug

CHEMBL501736

chembl501736

Open drug

CHEMBL511119

chembl511119

Open drug

CHEMBL524640

chembl524640

Open drug

CHEMBL247619

chembl247619

Open drug

CHEMBL198400

chembl198400

Open drug

CHEMBL484317

chembl484317

Open drug

CHEMBL498674

chembl498674

Open drug

CHEMBL200172

chembl200172

Open drug

CHEMBL1964275

chembl1964275

Open drug

CHEMBL483717

chembl483717

Open drug

CHEMBL486341

chembl486341

Open drug

CHEMBL199605

chembl199605

Open drug

CHEMBL450519

chembl450519

Open drug

CHEMBL370112

chembl370112

Open drug

CHEMBL373006

chembl373006

Open drug

CHEMBL394826

chembl394826

Open drug

CHEMBL1964267

chembl1964267

Open drug

CHEMBL475433

chembl475433

Open drug

CHEMBL398872

chembl398872

Open drug

CHEMBL483297

chembl483297

Open drug

CHEMBL482932

chembl482932

Open drug

CHEMBL485246

chembl485246

Open drug

CHEMBL496612

chembl496612

Open drug

CHEMBL521725

chembl521725

Open drug

CHEMBL509283

chembl509283

Open drug

CHEMBL459935

chembl459935

Open drug

CHEMBL498487

chembl498487

Open drug

CHEMBL496203

chembl496203

Open drug

CHEMBL518187

chembl518187

Open drug

CHEMBL199833

chembl199833

Open drug

CHEMBL400308

chembl400308

Open drug

CHEMBL490841

chembl490841

Open drug

CHEMBL500151

chembl500151

Open drug

CHEMBL498524

chembl498524

Open drug

LY-3009120

chembl3577124

Open drug

CHEMBL498317

chembl498317

Open drug

CHEMBL470808

chembl470808

Open drug

CHEMBL440761

chembl440761

Open drug

CHEMBL520623

chembl520623

Open drug

CHEMBL200431

chembl200431

Open drug

CHEMBL400057

chembl400057

Open drug

CHEMBL247250

chembl247250

Open drug

CHEMBL484106

chembl484106

Open drug

CHEMBL483718

chembl483718

Open drug

VEMURAFENIB

chembl1229517

Open drug

CHEMBL520627

chembl520627

Open drug

CHEMBL481681

chembl481681

Open drug

CHEMBL524507

chembl524507

Open drug

CHEMBL500142

chembl500142

Open drug

CHEMBL483914

chembl483914

Open drug

CHEMBL248257

chembl248257

Open drug

CHEMBL498307

chembl498307

Open drug

CHEMBL496479

chembl496479

Open drug

ALTENUSIN

chembl483531

Open drug

CHEMBL1964273

chembl1964273

Open drug

CHEMBL523261

chembl523261

Open drug

CHEMBL257167

chembl257167

Open drug

CHEMBL504075

chembl504075

Open drug

CHEMBL504135

chembl504135

Open drug

CHEMBL501686

chembl501686

Open drug

CHEMBL447317

chembl447317

Open drug

CHEMBL483921

chembl483921

Open drug

CHEMBL247618

chembl247618

Open drug

CHEMBL200114

chembl200114

Open drug

CHEMBL471415

chembl471415

Open drug

CHEMBL200164

chembl200164

Open drug

CHEMBL519976

chembl519976

Open drug

CHEMBL485302

chembl485302

Open drug

CHEMBL489229

chembl489229

Open drug

CHEMBL462473

chembl462473

Open drug

CHEMBL497670

chembl497670

Open drug

DABRAFENIB MESYLATE

chembl2105729

Open drug

CHEMBL247424

chembl247424

Open drug

CHEMBL497701

chembl497701

Open drug

CHEMBL523278

chembl523278

Open drug

CHEMBL401710

chembl401710

Open drug

CHEMBL201625

chembl201625

Open drug

CHEMBL248226

chembl248226

Open drug

CHEMBL199588

chembl199588

Open drug

CHEMBL454028

chembl454028

Open drug

CHEMBL496477

chembl496477

Open drug

CHEMBL481563

chembl481563

Open drug

CHEMBL480551

chembl480551

Open drug

CHEMBL471407

chembl471407

Open drug

CHEMBL201576

chembl201576

Open drug

CHEMBL200637

chembl200637

Open drug

CHEMBL470364

chembl470364

Open drug

CHEMBL484968

chembl484968

Open drug

CHEMBL477774

chembl477774

Open drug

CHEMBL515491

chembl515491

Open drug

CHEMBL482681

chembl482681

Open drug

CHEMBL491055

chembl491055

Open drug

CHEMBL501946

chembl501946

Open drug

CHEMBL426476

chembl426476

Open drug

CHEMBL471794

chembl471794

Open drug

CHEMBL520818

chembl520818

Open drug

CHEMBL459931

chembl459931

Open drug

CHEMBL476066

chembl476066

Open drug

CHEMBL521480

chembl521480

Open drug

CHEMBL248860

chembl248860

Open drug

CHEMBL489009

chembl489009

Open drug

CHEMBL526268

chembl526268

Open drug

CHEMBL482928

chembl482928

Open drug

CHEMBL485300

chembl485300

Open drug

CHEMBL487717

chembl487717

Open drug

CHEMBL497700

chembl497700

Open drug

CHEMBL519992

chembl519992

Open drug

CHEMBL475795

chembl475795

Open drug

CHEMBL482718

chembl482718

Open drug

CHEMBL255497

chembl255497

Open drug

CHEMBL486943

chembl486943

Open drug

HESPERADIN

chembl514409

Open drug

MALEIMIDE

chembl201511

Open drug

TALAROFLAVONE

chembl408995

Open drug

CHEMBL524812

chembl524812

Open drug

CHEMBL475865

chembl475865

Open drug

CHEMBL397345

chembl397345

Open drug

CHEMBL525191

chembl525191

Open drug

CHEMBL480200

chembl480200

Open drug

CHEMBL86755

chembl86755

Open drug

CHEMBL378600

chembl378600

Open drug

CHEMBL408019

chembl408019

Open drug

CHEMBL402424

chembl402424

Open drug

CHEMBL200964

chembl200964

Open drug

CHEMBL516655

chembl516655

Open drug

CHEMBL498344

chembl498344

Open drug

CHEMBL485299

chembl485299

Open drug

CHEMBL484319

chembl484319

Open drug

CHEMBL459714

chembl459714

Open drug

CHEMBL489228

chembl489228

Open drug

CHEMBL199355

chembl199355

Open drug

CHEMBL498327

chembl498327

Open drug

ALTERNARIENONIC ACID

chembl519395

Open drug

CHEMBL500660

chembl500660

Open drug

CHEMBL496409

chembl496409

Open drug

CHEMBL460136

chembl460136

Open drug

CHEMBL483709

chembl483709

Open drug

CHEMBL484301

chembl484301

Open drug

CHEMBL507714

chembl507714

Open drug

CHEMBL430413

chembl430413

Open drug

CHEMBL199281

chembl199281

Open drug

CHEMBL514688

chembl514688

Open drug

CHEMBL475794

chembl475794

Open drug

CHEMBL489842

chembl489842

Open drug

CHEMBL489823

chembl489823

Open drug

CHEMBL498503

chembl498503

Open drug

CHEMBL490454

chembl490454

Open drug

CHEMBL477987

chembl477987

Open drug

CHEMBL500416

chembl500416

Open drug

CHEMBL503699

chembl503699

Open drug

CHEMBL402029

chembl402029

Open drug

CHEMBL198244

chembl198244

Open drug

CHEMBL483525

chembl483525

Open drug

CHEMBL246423

chembl246423

Open drug

CHEMBL470799

chembl470799

Open drug

CHEMBL480389

chembl480389

Open drug

CHEMBL476859

chembl476859

Open drug

CHEMBL371694

chembl371694

Open drug

CHEMBL504906

chembl504906

Open drug

CHEMBL427196

chembl427196

Open drug

CHEMBL521731

chembl521731

Open drug
repoDB-style · approved-elsewhere discussion candidates

disease_drug_evidence rows on linked drugs whose evidence_type suggests approved-elsewhere discussion context.

No matching rows

Import repoDB-compatible disease–drug evidence or add structured rows to surface discussion candidates here.

ClinicalTrials.gov · trial-matched options

Mirror rows whose text fields mention this symbol — registry context only.

No matching live evidence found

Populate clinical_trials via the registry enrichment flow; this panel matches the symbol token in titles, conditions, or interventions.

CANTI signal builder · target-linked research signals

Repurposing signal rows for drugs linked to this target via drug_targets.

Repurposing research signal · ALTENUSIN · v0.1

Deterministic research signal for ALTENUSIN. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

Open signals hub

Repurposing research signal · CEP-32496 · v0.1

Deterministic research signal for CEP-32496. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

Open signals hub

Repurposing research signal · ALTERNARIOL · v0.1

Deterministic research signal for ALTERNARIOL. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

Open signals hub

Repurposing research signal · ALTERTOXIN I · v0.1

Deterministic research signal for ALTERTOXIN I. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

Open signals hub

Repurposing research signal · ALTERNARIENONIC ACID · v0.1

Deterministic research signal for ALTERNARIENONIC ACID. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

Open signals hub

Repurposing research signal · ARQ-736 · v0.1

Deterministic research signal for ARQ-736. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

Open signals hub

Repurposing research signal · ALTERLACTONE · v0.1

Deterministic research signal for ALTERLACTONE. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

Open signals hub
Caution / negative-evidence rows

Structured rows with negative evidence_direction on disease–drug or signal tables.

No negative-direction rows

When structured evidence includes explicit negative direction fields, they surface here for oncology review.

Missing evidence · row counts by source string

No ClinicalTrials.gov mirror rows mention this symbol in titles, conditions, or interventions (within the loaded window).

  • chembl: 500
  • canti_signal_builder: 7
  • opentargets: 1
Summary row (aggregated list)

Structured evidence rows link this marker to cohort contexts when ingested — interpret as research context only.

Disease contexts

0

Linked drugs

0

Linked in dataset

0

Research signals

0

Evidence badges (illustrative)

Doctor-discussion candidate and related tags are descriptive only.

Appears in source landscapeLinked in datasetRequires oncology review
Linked research signals (list read)

Signals list: Live structured evidence (Supabase)

Repurposing research signal · ALTERLACTONE · v0.1

Deterministic research signal for ALTERLACTONE. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

View signals hub

Repurposing research signal · ALTERPORRIOL G/H · v0.1

Deterministic research signal for ALTERPORRIOL G/H. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

View signals hub

Repurposing research signal · ALVOCIDIB · v0.1

Deterministic research signal for ALVOCIDIB. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

View signals hub

Repurposing research signal · ARQ-736 · v0.1

Deterministic research signal for ARQ-736. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

View signals hub

Repurposing research signal · ALTERNARIENONIC ACID · v0.1

Deterministic research signal for ALTERNARIENONIC ACID. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

View signals hub

Repurposing research signal · ALTERTOXIN I · v0.1

Deterministic research signal for ALTERTOXIN I. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

View signals hub

Repurposing research signal · ALTERSOLANOL A · v0.1

Deterministic research signal for ALTERSOLANOL A. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

View signals hub

Repurposing research signal · ALTERNARIOL · v0.1

Deterministic research signal for ALTERNARIOL. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

View signals hub

Repurposing research signal · CEP-32496 · v0.1

Deterministic research signal for CEP-32496. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

View signals hub

Repurposing research signal · CANERTINIB · v0.1

Deterministic research signal for CANERTINIB. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

View signals hub

Repurposing research signal · AST-487 · v0.1

Deterministic research signal for AST-487. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

View signals hub

Repurposing research signal · BMS-387032 · v0.1

Deterministic research signal for BMS-387032. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

View signals hub

Repurposing research signal · ALTENUSIN · v0.1

Deterministic research signal for ALTENUSIN. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

View signals hub