Target detail
ADAMTS4
ADAM metallopeptidase with thrombospondin type 1 motif 4
Data: Live structured evidence (Supabase)
Foundation row from public.targets — full Open Targets / ChEMBL preload remains a future operator job (Phase 8H+).
Display name: ADAM metallopeptidase with thrombospondin type 1 motif 4
Aliases: ADAMTS4, ADAM metallopeptidase with thrombospondin type 1 motif 4
Type / organism: protein_coding · Homo sapiens
Source: opentargets · ENSG00000158859
Index freshness: last_synced_at 2026-05-15T19:10:28.95+00:00 · updated 2026-05-15T19:10:29.464708+00:00
Limitations & build flags
- Read-only structured navigator
- No clinical outcome benefit inferred
- Trial presence does not imply success
- Drug identity may require normalization
- Terminated/withdrawn trials must remain visible
This symbol is listed in public.targets (operator seed or future preload). Connector-backed sections below may still show empty states until ChEMBL / Open Targets / ClinicalTrials.gov mirror rows exist for this marker.
Connectors represented in loaded rows for ADAMTS4. Empty groups mean no matching rows — not a claim about biology or clinical use.
- Open TargetsLive when indexed
Disease–target evidence rows when operators run enrich:opentargets (GraphQL from trusted scripts only).
- ChEMBLLive when indexed
Drug–target and related enrichment rows when operators run enrich:chembl (server/CLI only).
- CANTI signal builderLive when indexed
Deterministic repurposing-signal rows produced by the in-repo signal builder when operators run the build pipeline.
Rows from disease_target_evidence for this symbol.
glioblastoma
literature · opentargets
Drug records tied via drug_targets — mechanistic linkage only.
CHEMBL1683448
chembl1683448
CHEMBL5834003
chembl5834003
CHEMBL1784356
chembl1784356
CHEMBL5592306
chembl5592306
CHEMBL3622478
chembl3622478
CHEMBL197842
chembl197842
CHEMBL5266587
chembl5266587
CHEMBL425020
chembl425020
CHEMBL2437170
chembl2437170
CHEMBL5868539
chembl5868539
CHEMBL6004626
chembl6004626
CHEMBL1807393
chembl1807393
CHEMBL275053
chembl275053
CHEMBL3622508
chembl3622508
CHEMBL5968483
chembl5968483
CHEMBL5826997
chembl5826997
CHEMBL466321
chembl466321
CHEMBL1910452
chembl1910452
CHEMBL237366
chembl237366
CHEMBL1683465
chembl1683465
CHEMBL5924769
chembl5924769
CHEMBL3622496
chembl3622496
CHEMBL4850670
chembl4850670
CHEMBL1910455
chembl1910455
CHEMBL1807402
chembl1807402
CHEMBL1784349
chembl1784349
CHEMBL1910454
chembl1910454
CHEMBL5268743
chembl5268743
CHEMBL5851756
chembl5851756
CHEMBL5998565
chembl5998565
CHEMBL373058
chembl373058
CHEMBL1784369
chembl1784369
CHEMBL4094455
chembl4094455
CHEMBL200888
chembl200888
CHEMBL5768101
chembl5768101
CHEMBL1683453
chembl1683453
CHEMBL372405
chembl372405
CHEMBL2348116
chembl2348116
CHEMBL1784338
chembl1784338
CHEMBL5290839
chembl5290839
CHEMBL512803
chembl512803
CHEMBL199631
chembl199631
CHEMBL3622491
chembl3622491
CHEMBL1784341
chembl1784341
CHEMBL1784365
chembl1784365
CHEMBL1910453
chembl1910453
CHEMBL4873384
chembl4873384
CHEMBL472144
chembl472144
CHEMBL183886
chembl183886
CHEMBL360175
chembl360175
CHEMBL1807219
chembl1807219
CHEMBL1683456
chembl1683456
CHEMBL1784344
chembl1784344
CHEMBL49411
chembl49411
CHEMBL5593176
chembl5593176
CHEMBL1683450
chembl1683450
CHEMBL5841723
chembl5841723
CHEMBL3358151
chembl3358151
CHEMBL1615187
chembl1615187
CHEMBL1683443
chembl1683443
CHEMBL182880
chembl182880
CHEMBL562003
chembl562003
CHEMBL1683460
chembl1683460
CHEMBL1940315
chembl1940315
CHEMBL5881746
chembl5881746
CHEMBL3622488
chembl3622488
CHEMBL466117
chembl466117
CHEMBL1784337
chembl1784337
CHEMBL4846457
chembl4846457
CHEMBL5832289
chembl5832289
CHEMBL2437164
chembl2437164
CHEMBL445140
chembl445140
CHEMBL5934389
chembl5934389
CHEMBL1078281
chembl1078281
CHEMBL3358153
chembl3358153
CHEMBL1910463
chembl1910463
CHEMBL2437173
chembl2437173
CHEMBL187092
chembl187092
CHEMBL5923162
chembl5923162
CHEMBL187852
chembl187852
CHEMBL1910449
chembl1910449
CHEMBL5798314
chembl5798314
CHEMBL1683462
chembl1683462
CHEMBL200269
chembl200269
CHEMBL1683451
chembl1683451
CHEMBL183935
chembl183935
CHEMBL184501
chembl184501
CHEMBL194430
chembl194430
CHEMBL473326
chembl473326
CHEMBL1784353
chembl1784353
CHEMBL5914760
chembl5914760
CHEMBL179552
chembl179552
PYROGALLOL
chembl307145
CHEMBL5933095
chembl5933095
CHEMBL466118
chembl466118
CHEMBL2337690
chembl2337690
CHEMBL466264
chembl466264
CHEMBL5875518
chembl5875518
CHEMBL2337691
chembl2337691
CHEMBL1683463
chembl1683463
CHEMBL1784366
chembl1784366
CHEMBL5961606
chembl5961606
CHEMBL5930679
chembl5930679
ILOMASTAT
chembl19611
CHEMBL360704
chembl360704
CHEMBL1683454
chembl1683454
CHEMBL198778
chembl198778
CHEMBL5286469
chembl5286469
CHEMBL2047536
chembl2047536
CHEMBL1910441
chembl1910441
CHEMBL466881
chembl466881
CHEMBL237149
chembl237149
CHEMBL1910448
chembl1910448
CHEMBL1683446
chembl1683446
CHEMBL1910476
chembl1910476
CHEMBL1910456
chembl1910456
CHEMBL446694
chembl446694
CHEMBL200466
chembl200466
CHEMBL1784362
chembl1784362
CHEMBL200225
chembl200225
CHEMBL501414
chembl501414
CHEMBL3622489
chembl3622489
CHEMBL1910474
chembl1910474
CHEMBL4589438
chembl4589438
CHEMBL2337696
chembl2337696
CHEMBL382117
chembl382117
CHEMBL185158
chembl185158
CHEMBL183936
chembl183936
CHEMBL1910458
chembl1910458
CHEMBL199943
chembl199943
CHEMBL467509
chembl467509
CHEMBL5987738
chembl5987738
CHEMBL372158
chembl372158
CHEMBL1683457
chembl1683457
CHEMBL4859812
chembl4859812
CHEMBL1683444
chembl1683444
CHEMBL5935128
chembl5935128
CHEMBL3622481
chembl3622481
CHEMBL1910472
chembl1910472
CHEMBL1807399
chembl1807399
CHEMBL5268022
chembl5268022
CHEMBL3358157
chembl3358157
CHEMBL1807405
chembl1807405
CHEMBL1269962
chembl1269962
CHEMBL183273
chembl183273
CHEMBL1910471
chembl1910471
CHEMBL4072836
chembl4072836
CHEMBL6046559
chembl6046559
CHEMBL4877087
chembl4877087
CHEMBL3622506
chembl3622506
CHEMBL365947
chembl365947
CHEMBL1910470
chembl1910470
CHEMBL5939068
chembl5939068
CHEMBL1910651
chembl1910651
CHEMBL1784339
chembl1784339
CHEMBL184065
chembl184065
CHEMBL523034
chembl523034
CHEMBL208009
chembl208009
CHEMBL1766896
chembl1766896
CHEMBL184190
chembl184190
CHEMBL5288351
chembl5288351
CHEMBL197703
chembl197703
CHEMBL1784359
chembl1784359
PICEATANNOL
chembl69863
CHEMBL2348100
chembl2348100
CHEMBL1683458
chembl1683458
CHEMBL3104658
chembl3104658
CHEMBL187141
chembl187141
CHEMBL1784363
chembl1784363
CHEMBL468511
chembl468511
CHEMBL1784357
chembl1784357
CHEMBL1940308
chembl1940308
CHEMBL1767014
chembl1767014
CHEMBL1807396
chembl1807396
CHEMBL4864283
chembl4864283
CHEMBL5768118
chembl5768118
CHEMBL5267646
chembl5267646
CHEMBL3622498
chembl3622498
CHEMBL1910468
chembl1910468
CHEMBL3622479
chembl3622479
CHEMBL5920898
chembl5920898
CHEMBL5290512
chembl5290512
CHEMBL467690
chembl467690
CHEMBL5910236
chembl5910236
CHEMBL512804
chembl512804
CHEMBL1784352
chembl1784352
CHEMBL2337697
chembl2337697
CHEMBL5960456
chembl5960456
CHEMBL480567
chembl480567
CHEMBL5904610
chembl5904610
CHEMBL4874034
chembl4874034
CHEMBL1910460
chembl1910460
CHEMBL5891291
chembl5891291
CHEMBL1683464
chembl1683464
CHEMBL4066965
chembl4066965
CHEMBL1910442
chembl1910442
CHEMBL3622497
chembl3622497
CHEMBL1270566
chembl1270566
CHEMBL3358156
chembl3358156
CHEMBL5740606
chembl5740606
disease_drug_evidence rows on linked drugs whose evidence_type suggests approved-elsewhere discussion context.
No matching rows
Import repoDB-compatible disease–drug evidence or add structured rows to surface discussion candidates here.
Mirror rows whose text fields mention this symbol — registry context only.
No matching live evidence found
Populate clinical_trials via the registry enrichment flow; this panel matches the symbol token in titles, conditions, or interventions.
Repurposing signal rows for drugs linked to this target via drug_targets.
Repurposing research signal · CGS-27023A · v0.1
Deterministic research signal for CGS-27023A. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
Open signals hubStructured rows with negative evidence_direction on disease–drug or signal tables.
No negative-direction rows
When structured evidence includes explicit negative direction fields, they surface here for oncology review.
No ClinicalTrials.gov mirror rows mention this symbol in titles, conditions, or interventions (within the loaded window).
- chembl: 448
- opentargets: 1
- canti_signal_builder: 1
Structured evidence rows link this marker to cohort contexts when ingested — interpret as research context only.
Disease contexts
0
Linked drugs
0
Linked in dataset
0
Research signals
0
Doctor-discussion candidate and related tags are descriptive only.
Signals list: Live structured evidence (Supabase)
Repurposing research signal · CGS-27023A · v0.1
Deterministic research signal for CGS-27023A. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hub