Target detail
ADAM8
ADAM metallopeptidase domain 8
Data: Live structured evidence (Supabase)
Foundation row from public.targets — full Open Targets / ChEMBL preload remains a future operator job (Phase 8H+).
Display name: ADAM metallopeptidase domain 8
Aliases: ADAM8, ADAM metallopeptidase domain 8
Type / organism: protein_coding · Homo sapiens
Source: opentargets · ENSG00000151651
Index freshness: last_synced_at 2026-05-15T19:30:20.493+00:00 · updated 2026-05-15T19:30:21.039683+00:00
Limitations & build flags
- Read-only structured navigator
- No clinical outcome benefit inferred
- Trial presence does not imply success
- Drug identity may require normalization
- Terminated/withdrawn trials must remain visible
This symbol is listed in public.targets (operator seed or future preload). Connector-backed sections below may still show empty states until ChEMBL / Open Targets / ClinicalTrials.gov mirror rows exist for this marker.
Connectors represented in loaded rows for ADAM8. Empty groups mean no matching rows — not a claim about biology or clinical use.
- Open TargetsLive when indexed
Disease–target evidence rows when operators run enrich:opentargets (GraphQL from trusted scripts only).
- ChEMBLLive when indexed
Drug–target and related enrichment rows when operators run enrich:chembl (server/CLI only).
Rows from disease_target_evidence for this symbol.
glioblastoma
literature · opentargets
Drug records tied via drug_targets — mechanistic linkage only.
CHEMBL448246
chembl448246
CHEMBL3827980
chembl3827980
CHEMBL3827446
chembl3827446
CHEMBL473326
chembl473326
CHEMBL3828456
chembl3828456
CHEMBL3828603
chembl3828603
CHEMBL3828497
chembl3828497
CHEMBL3827625
chembl3827625
CHEMBL3827271
chembl3827271
CHEMBL3828432
chembl3828432
CHEMBL434567
chembl434567
CHEMBL3827732
chembl3827732
CHEMBL5283335
chembl5283335
CHEMBL2431028
chembl2431028
CHEMBL3827091
chembl3827091
CHEMBL3828248
chembl3828248
CHEMBL500351
chembl500351
CHEMBL3828319
chembl3828319
CHEMBL3827131
chembl3827131
CHEMBL3827487
chembl3827487
CHEMBL3827027
chembl3827027
CHEMBL5575976
chembl5575976
CHEMBL5276957
chembl5276957
CHEMBL5267938
chembl5267938
CHEMBL3827850
chembl3827850
CHEMBL3827893
chembl3827893
CHEMBL3827647
chembl3827647
CHEMBL3827100
chembl3827100
disease_drug_evidence rows on linked drugs whose evidence_type suggests approved-elsewhere discussion context.
No matching rows
Import repoDB-compatible disease–drug evidence or add structured rows to surface discussion candidates here.
Mirror rows whose text fields mention this symbol — registry context only.
No matching live evidence found
Populate clinical_trials via the registry enrichment flow; this panel matches the symbol token in titles, conditions, or interventions.
Repurposing signal rows for drugs linked to this target via drug_targets.
No research signals for linked drugs
Run the deterministic signal builder after drug_targets and source rows are present.
Structured rows with negative evidence_direction on disease–drug or signal tables.
No negative-direction rows
When structured evidence includes explicit negative direction fields, they surface here for oncology review.
No ClinicalTrials.gov mirror rows mention this symbol in titles, conditions, or interventions (within the loaded window).
- chembl: 28
- opentargets: 1
Structured evidence rows link this marker to cohort contexts when ingested — interpret as research context only.
Disease contexts
0
Linked drugs
0
Linked in dataset
0
Research signals
0
Doctor-discussion candidate and related tags are descriptive only.
Signals list: Live structured evidence (Supabase)
No matching live evidence found
When repurposing_signal rows reference this marker via linked drugs, summaries appear here.