Target detail
ADAM10
ADAM metallopeptidase domain 10
Data: Live structured evidence (Supabase)
Foundation row from public.targets — full Open Targets / ChEMBL preload remains a future operator job (Phase 8H+).
Display name: ADAM metallopeptidase domain 10
Aliases: ADAM10, ADAM metallopeptidase domain 10
Type / organism: protein_coding · Homo sapiens
Source: opentargets · ENSG00000137845
Index freshness: last_synced_at 2026-05-15T17:56:46.965+00:00 · updated 2026-05-15T17:56:47.365021+00:00
Limitations & build flags
- Read-only structured navigator
- No clinical outcome benefit inferred
- Trial presence does not imply success
- Drug identity may require normalization
- Terminated/withdrawn trials must remain visible
This symbol is listed in public.targets (operator seed or future preload). Connector-backed sections below may still show empty states until ChEMBL / Open Targets / ClinicalTrials.gov mirror rows exist for this marker.
Connectors represented in loaded rows for ADAM10. Empty groups mean no matching rows — not a claim about biology or clinical use.
- Open TargetsLive when indexed
Disease–target evidence rows when operators run enrich:opentargets (GraphQL from trusted scripts only).
- ChEMBLLive when indexed
Drug–target and related enrichment rows when operators run enrich:chembl (server/CLI only).
- CANTI signal builderLive when indexed
Deterministic repurposing-signal rows produced by the in-repo signal builder when operators run the build pipeline.
Rows from disease_target_evidence for this symbol.
glioblastoma
literature · opentargets
Drug records tied via drug_targets — mechanistic linkage only.
CHEMBL3235911
chembl3235911
CHEMBL3593542
chembl3593542
CHEMBL253890
chembl253890
CHEMBL584120
chembl584120
CHEMBL484261
chembl484261
CHEMBL253019
chembl253019
CHEMBL3648907
chembl3648907
CHEMBL221857
chembl221857
CHEMBL439405
chembl439405
CHEMBL253035
chembl253035
CHEMBL254508
chembl254508
CHEMBL4105563
chembl4105563
CHEMBL375418
chembl375418
CHEMBL427717
chembl427717
CHEMBL1779630
chembl1779630
CHEMBL252830
chembl252830
CHEMBL566233
chembl566233
CHEMBL4873384
chembl4873384
CHEMBL585304
chembl585304
CHEMBL404170
chembl404170
CHEMBL3648903
chembl3648903
CHEMBL495555
chembl495555
CHEMBL576061
chembl576061
CHEMBL3392650
chembl3392650
CHEMBL366034
chembl366034
CHEMBL1287851
chembl1287851
CHEMBL496309
chembl496309
CHEMBL252246
chembl252246
CHEMBL1222867
chembl1222867
CHEMBL3593360
chembl3593360
CHEMBL496628
chembl496628
CHEMBL586042
chembl586042
CHEMBL523076
chembl523076
CHEMBL251823
chembl251823
CHEMBL3593359
chembl3593359
CHEMBL497810
chembl497810
CHEMBL218586
chembl218586
CHEMBL4215407
chembl4215407
CHEMBL473326
chembl473326
CHEMBL426388
chembl426388
CHEMBL251848
chembl251848
CHEMBL429669
chembl429669
CHEMBL1770826
chembl1770826
CHEMBL253452
chembl253452
CHEMBL4102106
chembl4102106
CHEMBL401870
chembl401870
CHEMBL3593551
chembl3593551
CHEMBL2431021
chembl2431021
CHEMBL404093
chembl404093
ILOMASTAT
chembl19611
GRASSYSTATIN C
chembl569445
CHEMBL496211
chembl496211
CHEMBL3593552
chembl3593552
CHEMBL497032
chembl497032
CHEMBL3770935
chembl3770935
CHEMBL252442
chembl252442
CHEMBL4078433
chembl4078433
APRATASTAT
chembl206815
CHEMBL591774
chembl591774
GRASSYSTATIN A
chembl567893
CHEMBL399351
chembl399351
CHEMBL4205925
chembl4205925
CHEMBL442443
chembl442443
CHEMBL252278
chembl252278
CHEMBL254295
chembl254295
CHEMBL4081997
chembl4081997
CHEMBL3966632
chembl3966632
CHEMBL251865
chembl251865
CHEMBL3935135
chembl3935135
CHEMBL253665
chembl253665
CHEMBL496825
chembl496825
CHEMBL251820
chembl251820
CHEMBL252023
chembl252023
CHEMBL4167357
chembl4167357
CHEMBL188414
chembl188414
CHEMBL585886
chembl585886
CHEMBL497222
chembl497222
CHEMBL219104
chembl219104
CHEMBL434567
chembl434567
CHEMBL4216076
chembl4216076
CHEMBL572045
chembl572045
CHEMBL269834
chembl269834
CHEMBL253230
chembl253230
CHEMBL497769
chembl497769
CHEMBL3593545
chembl3593545
CHEMBL404132
chembl404132
CHEMBL4080520
chembl4080520
CHEMBL5206579
chembl5206579
CHEMBL3704919
chembl3704919
CHEMBL253020
chembl253020
CHEMBL3593547
chembl3593547
CHEMBL1204013
chembl1204013
CHEMBL496829
chembl496829
CHEMBL3648905
chembl3648905
CHEMBL1770629
chembl1770629
CHEMBL253920
chembl253920
CHEMBL252612
chembl252612
CHEMBL252627
chembl252627
CHEMBL446457
chembl446457
CHEMBL3941484
chembl3941484
CHEMBL5283335
chembl5283335
CHEMBL402954
chembl402954
CHEMBL4435465
chembl4435465
CHEMBL1089842
chembl1089842
CHEMBL254492
chembl254492
CHEMBL4206683
chembl4206683
CHEMBL221120
chembl221120
CGS-27023A
chembl514138
CHEMBL398743
chembl398743
CHEMBL4209993
chembl4209993
MARIMASTAT
chembl279785
CHEMBL252024
chembl252024
CHEMBL251847
chembl251847
CHEMBL1229516
chembl1229516
CHEMBL365261
chembl365261
CHEMBL3593361
chembl3593361
CHEMBL3593550
chembl3593550
CHEMBL3704903
chembl3704903
CHEMBL4208519
chembl4208519
CHEMBL442432
chembl442432
CHEMBL584334
chembl584334
CHEMBL497985
chembl497985
CHEMBL253021
chembl253021
CHEMBL2431028
chembl2431028
CHEMBL521719
chembl521719
CHEMBL489100
chembl489100
CHEMBL590343
chembl590343
CHEMBL3770688
chembl3770688
CHEMBL461220
chembl461220
CHEMBL4215451
chembl4215451
CHEMBL1223075
chembl1223075
CHEMBL3648902
chembl3648902
CHEMBL497026
chembl497026
CHEMBL373532
chembl373532
CHEMBL496629
chembl496629
CHEMBL1093690
chembl1093690
CHEMBL605764
chembl605764
CHEMBL3704910
chembl3704910
CHEMBL572091
chembl572091
CHEMBL254510
chembl254510
CHEMBL403161
chembl403161
CHEMBL252081
chembl252081
CHEMBL253275
chembl253275
CHEMBL3221864
chembl3221864
CHEMBL253652
chembl253652
CHEMBL3593544
chembl3593544
CHEMBL569388
chembl569388
CHEMBL1092104
chembl1092104
CHEMBL568346
chembl568346
CHEMBL495502
chembl495502
CHEMBL1088878
chembl1088878
CHEMBL252877
chembl252877
CHEMBL500351
chembl500351
CHEMBL220501
chembl220501
CHEMBL3221863
chembl3221863
CHEMBL4217240
chembl4217240
CHEMBL3593549
chembl3593549
CHEMBL252079
chembl252079
CHEMBL496018
chembl496018
CHEMBL442291
chembl442291
CHEMBL496212
chembl496212
CHEMBL585299
chembl585299
CHEMBL3593362
chembl3593362
CHEMBL570760
chembl570760
CHEMBL569853
chembl569853
CHEMBL3648893
chembl3648893
CHEMBL404409
chembl404409
CHEMBL1223007
chembl1223007
CHEMBL1090647
chembl1090647
CHEMBL3897740
chembl3897740
CHEMBL3643916
chembl3643916
CHEMBL1093689
chembl1093689
CHEMBL495596
chembl495596
CHEMBL5575976
chembl5575976
CHEMBL569166
chembl569166
CHEMBL2431026
chembl2431026
CHEMBL3593357
chembl3593357
CHEMBL3593543
chembl3593543
CHEMBL254715
chembl254715
CHEMBL445717
chembl445717
CHEMBL3593548
chembl3593548
CHEMBL1077203
chembl1077203
CHEMBL3648906
chembl3648906
CHEMBL373853
chembl373853
CHEMBL3648904
chembl3648904
CHEMBL567940
chembl567940
CHEMBL506057
chembl506057
CHEMBL568356
chembl568356
CHEMBL5276957
chembl5276957
CHEMBL567939
chembl567939
CHEMBL221698
chembl221698
CHEMBL252678
chembl252678
CHEMBL252912
chembl252912
CHEMBL361087
chembl361087
CHEMBL221537
chembl221537
CHEMBL4214929
chembl4214929
CHEMBL3593356
chembl3593356
CHEMBL5267938
chembl5267938
CHEMBL253460
chembl253460
CHEMBL2431027
chembl2431027
disease_drug_evidence rows on linked drugs whose evidence_type suggests approved-elsewhere discussion context.
No matching rows
Import repoDB-compatible disease–drug evidence or add structured rows to surface discussion candidates here.
Mirror rows whose text fields mention this symbol — registry context only.
No matching live evidence found
Populate clinical_trials via the registry enrichment flow; this panel matches the symbol token in titles, conditions, or interventions.
Repurposing signal rows for drugs linked to this target via drug_targets.
Repurposing research signal · APRATASTAT · v0.1
Deterministic research signal for APRATASTAT. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
Open signals hubRepurposing research signal · CGS-27023A · v0.1
Deterministic research signal for CGS-27023A. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
Open signals hubStructured rows with negative evidence_direction on disease–drug or signal tables.
No negative-direction rows
When structured evidence includes explicit negative direction fields, they surface here for oncology review.
No ClinicalTrials.gov mirror rows mention this symbol in titles, conditions, or interventions (within the loaded window).
- chembl: 232
- canti_signal_builder: 2
- opentargets: 1
Structured evidence rows link this marker to cohort contexts when ingested — interpret as research context only.
Disease contexts
0
Linked drugs
0
Linked in dataset
0
Research signals
0
Doctor-discussion candidate and related tags are descriptive only.
Signals list: Live structured evidence (Supabase)
Repurposing research signal · APRATASTAT · v0.1
Deterministic research signal for APRATASTAT. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hubRepurposing research signal · CGS-27023A · v0.1
Deterministic research signal for CGS-27023A. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hub