Target detail
ACVR1B
activin A receptor type 1B
Data: Live structured evidence (Supabase)
Foundation row from public.targets — full Open Targets / ChEMBL preload remains a future operator job (Phase 8H+).
Display name: activin A receptor type 1B
Aliases: ACVR1B, activin A receptor type 1B
Type / organism: protein_coding · Homo sapiens
Source: opentargets · ENSG00000135503
Index freshness: last_synced_at 2026-05-15T17:39:28.372+00:00 · updated 2026-05-15T17:39:28.717718+00:00
Limitations & build flags
- Read-only structured navigator
- No clinical outcome benefit inferred
- Trial presence does not imply success
- Drug identity may require normalization
- Terminated/withdrawn trials must remain visible
This symbol is listed in public.targets (operator seed or future preload). Connector-backed sections below may still show empty states until ChEMBL / Open Targets / ClinicalTrials.gov mirror rows exist for this marker.
Connectors represented in loaded rows for ACVR1B. Empty groups mean no matching rows — not a claim about biology or clinical use.
- Open TargetsLive when indexed
Disease–target evidence rows when operators run enrich:opentargets (GraphQL from trusted scripts only).
- ChEMBLLive when indexed
Drug–target and related enrichment rows when operators run enrich:chembl (server/CLI only).
- CANTI signal builderLive when indexed
Deterministic repurposing-signal rows produced by the in-repo signal builder when operators run the build pipeline.
Rows from disease_target_evidence for this symbol.
glioblastoma
literature · opentargets
Drug records tied via drug_targets — mechanistic linkage only.
PD-169316
chembl17331
CHEMBL511337
chembl511337
CHEMBL1829512
chembl1829512
CHEMBL478649
chembl478649
PELITINIB
chembl607707
TUCATINIB
chembl3989868
VX-702
chembl1090090
PAXALISIB
chembl3813842
AMG-208
chembl496102
CHEMBL596380
chembl596380
TOVORAFENIB
chembl3348923
CHEMBL266325
chembl266325
PAZOPANIB
chembl477772
AST-487
chembl574738
CHEMBL3099673
chembl3099673
STAUROSPORINE
chembl388978
CHEMBL1363184
chembl1363184
CHEMBL516312
chembl516312
CHEMBL64758
chembl64758
ENCORAFENIB
chembl3301612
REGORAFENIB
chembl1946170
CHEMBL284861
chembl284861
CHEMBL526901
chembl526901
A-443654
chembl379300
SORAFENIB
chembl1336
CHEMBL97771
chembl97771
CHEMBL1802727
chembl1802727
ANILINOQUINAZOLINE1
chembl382590
BMS-754807
chembl575448
CHEMBL1233882
chembl1233882
CHEMBL3236464
chembl3236464
GW632580X
chembl261849
CHEMBL595545
chembl595545
CHEMBL551623
chembl551623
CHEMBL235658
chembl235658
VANDETANIB
chembl24828
SP-600125
chembl1725279
CHEMBL47940
chembl47940
CHEMBL562347
chembl562347
CRIZOTINIB
chembl601719
ANILINOPYRIMIDINE1
chembl383899
CHEMBL1964275
chembl1964275
CHEMBL607196
chembl607196
PACRITINIB
chembl2035187
CHEMBL450519
chembl450519
CHEMBL1822054
chembl1822054
CHELERYTHRINE
chembl13045
GALUNISERTIB
chembl2364611
ENZASTAURIN
chembl300138
AFATINIB
chembl1173655
COBIMETINIB
chembl2146883
INDIRUBIN-3-MONOXIME
chembl126077
XL-019
chembl3545328
AZD-4547
chembl3184679
CHEMBL3629616
chembl3629616
6BIO
chembl409450
MK-5108
chembl3600873
AZD-8186
chembl3408248
HMN-214
chembl3991927
TAK-593
chembl2180604
TIVOZANIB
chembl1289494
CHEMBL551021
chembl551021
FOSTAMATINIB
chembl2103830
FEDRATINIB
chembl1287853
CHEMBL261491
chembl261491
PONATINIB
chembl1171837
CHEMBL1829505
chembl1829505
AG1295
chembl7724
CHEMBL1829602
chembl1829602
CHEMBL1644616
chembl1644616
CHEMBL410456
chembl410456
VACTOSERTIB
chembl3260567
CHEMBL2017253
chembl2017253
CYC-116
chembl482967
CHEMBL1186409
chembl1186409
DANUSERTIB
chembl402548
CHEMBL1987813
chembl1987813
CHEMBL1081678
chembl1081678
CHEMBL2218936
chembl2218936
CHEMBL1828640
chembl1828640
PHA-665752
chembl450786
CHEMBL1684525
chembl1684525
CHEMBL258844
chembl258844
PI-103
chembl573339
BOHEMINE
chembl83980
CHEMBL594371
chembl594371
CHEMBL257167
chembl257167
CHEMBL65063
chembl65063
CHEMBL1802485
chembl1802485
CHEMBL2218939
chembl2218939
CHEMBL2218930
chembl2218930
CHEMBL404939
chembl404939
SARACATINIB
chembl217092
MK-2206
chembl1079175
CHEMBL3818173
chembl3818173
CHEMBL328710
chembl328710
CHEMBL1331734
chembl1331734
LESTAURTINIB
chembl603469
SB-202190
chembl278041
CHEMBL1684662
chembl1684662
CHEMBL1163518
chembl1163518
CHEMBL1164180
chembl1164180
AMG-900
chembl2140408
BOSUTINIB
chembl288441
PICTILISIB
chembl521851
CHEMBL2030402
chembl2030402
DORSOMORPHIN
chembl478629
CHEMBL3298678
chembl3298678
BX-795
chembl577784
NILOTINIB
chembl255863
MOTESANIB
chembl572881
CHEMBL2425654
chembl2425654
ENMD-2076
chembl482968
CHEMBL3758502
chembl3758502
CHEMBL28324
chembl28324
CHEMBL379787
chembl379787
CHEMBL573578
chembl573578
CHEMBL1164265
chembl1164265
AV-412 FREE BASE
chembl2138625
CHEMBL3884319
chembl3884319
CHEMBL1908395
chembl1908395
CHEMBL1241578
chembl1241578
CHEMBL1231533
chembl1231533
CHEMBL552429
chembl552429
SB-220025
chembl274064
CHEMBL4084193
chembl4084193
CHEMBL1829509
chembl1829509
CHEMBL3628627
chembl3628627
CHEMBL1164181
chembl1164181
SU-11652
chembl13485
CHEMBL2425646
chembl2425646
HESPERADIN
chembl514409
PALBOCICLIB
chembl189963
FASCAPLYSIN
chembl602937
TG100-115
chembl230011
CHEMBL525191
chembl525191
LY-294002
chembl98350
CHEMBL86755
chembl86755
MEISOINDIGO
chembl607535
CHEMBL408019
chembl408019
CHEMBL473773
chembl473773
RUBOXISTAURIN
chembl91829
CHEMBL424676
chembl424676
GSK-461364
chembl1908394
SAR-407899 FREE BASE
chembl1667969
OSIMERTINIB
chembl3353410
CHEMBL3688339
chembl3688339
TEMSIROLIMUS
chembl1201182
LINIFANIB
chembl223360
CHEMBL120077
chembl120077
CHEMBL1829507
chembl1829507
PF-04691502
chembl1234354
CHEMBL311228
chembl311228
CHEMBL1171523
chembl1171523
CHEMBL2385596
chembl2385596
SU-014813
chembl1721885
CHEMBL604483
chembl604483
CHEMBL560346
chembl560346
CHEMBL104264
chembl104264
LENVATINIB
chembl1289601
CHEMBL2348862
chembl2348862
CHEMBL382799
chembl382799
IDELALISIB
chembl2216870
CHEMBL2063926
chembl2063926
CHEMBL595546
chembl595546
CHEMBL1233881
chembl1233881
CHEMBL191384
chembl191384
CHEMBL1240885
chembl1240885
CHEMBL406375
chembl406375
CHEMBL3991935
chembl3991935
CHEMBL2385579
chembl2385579
BRIVANIB
chembl377300
CHEMBL3629013
chembl3629013
CHEMBL101683
chembl101683
CHEMBL1829506
chembl1829506
CHEMBL1076555
chembl1076555
KW-2449
chembl1908397
CHEMBL249097
chembl249097
CHEMBL3771285
chembl3771285
CHEMBL210618
chembl210618
CHEMBL1908396
chembl1908396
PF-03814735
chembl4289017
CHEMBL599894
chembl599894
CHEMBL288064
chembl288064
SONOLISIB
chembl411907
QUINOXALINE1
chembl259389
CHEMBL2402081
chembl2402081
CHEMBL1934353
chembl1934353
SELUMETINIB
chembl1614701
SB-202474
chembl278724
CHEMBL471901
chembl471901
DEFACTINIB
chembl3137331
CHEMBL2218940
chembl2218940
CHEMBL155333
chembl155333
CHEMBL515466
chembl515466
CERITINIB
chembl2403108
CHEMBL2376648
chembl2376648
CHEMBL2425644
chembl2425644
CHEMBL2385591
chembl2385591
NMS-1286937
chembl1094408
disease_drug_evidence rows on linked drugs whose evidence_type suggests approved-elsewhere discussion context.
No matching rows
Import repoDB-compatible disease–drug evidence or add structured rows to surface discussion candidates here.
Mirror rows whose text fields mention this symbol — registry context only.
No matching live evidence found
Populate clinical_trials via the registry enrichment flow; this panel matches the symbol token in titles, conditions, or interventions.
Repurposing signal rows for drugs linked to this target via drug_targets.
Repurposing research signal · BAFETINIB · v0.1
Deterministic research signal for BAFETINIB. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
Open signals hubRepurposing research signal · AT-9283 · v0.1
Deterministic research signal for AT-9283. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
Open signals hubRepurposing research signal · CHEMBL120077 · v0.1
Deterministic research signal for CHEMBL120077. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
Open signals hubRepurposing research signal · AST-487 · v0.1
Deterministic research signal for AST-487. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
Open signals hubRepurposing research signal · BMS-387032 · v0.1
Deterministic research signal for BMS-387032. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
Open signals hubRepurposing research signal · BOSUTINIB · v0.1
Deterministic research signal for BOSUTINIB. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
Open signals hubRepurposing research signal · CANERTINIB · v0.1
Deterministic research signal for CANERTINIB. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
Open signals hubRepurposing research signal · CHEMBL104468 · v0.1
Deterministic research signal for CHEMBL104468. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
Open signals hubRepurposing research signal · CHEMBL1221601 · v0.1
Deterministic research signal for CHEMBL1221601. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
Open signals hubRepurposing research signal · ALVOCIDIB · v0.1
Deterministic research signal for ALVOCIDIB. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
Open signals hubStructured rows with negative evidence_direction on disease–drug or signal tables.
No negative-direction rows
When structured evidence includes explicit negative direction fields, they surface here for oncology review.
No ClinicalTrials.gov mirror rows mention this symbol in titles, conditions, or interventions (within the loaded window).
- chembl: 491
- canti_signal_builder: 10
- opentargets: 1
Structured evidence rows link this marker to cohort contexts when ingested — interpret as research context only.
Disease contexts
0
Linked drugs
0
Linked in dataset
0
Research signals
0
Doctor-discussion candidate and related tags are descriptive only.
Signals list: Live structured evidence (Supabase)
Repurposing research signal · ALVOCIDIB · v0.1
Deterministic research signal for ALVOCIDIB. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hubRepurposing research signal · CHEMBL1221601 · v0.1
Deterministic research signal for CHEMBL1221601. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hubRepurposing research signal · CHEMBL104468 · v0.1
Deterministic research signal for CHEMBL104468. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hubRepurposing research signal · CANERTINIB · v0.1
Deterministic research signal for CANERTINIB. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hubRepurposing research signal · BOSUTINIB · v0.1
Deterministic research signal for BOSUTINIB. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hubRepurposing research signal · AST-487 · v0.1
Deterministic research signal for AST-487. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hubRepurposing research signal · BMS-387032 · v0.1
Deterministic research signal for BMS-387032. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hubRepurposing research signal · CHEMBL120077 · v0.1
Deterministic research signal for CHEMBL120077. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hubRepurposing research signal · AT-9283 · v0.1
Deterministic research signal for AT-9283. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hubRepurposing research signal · BAFETINIB · v0.1
Deterministic research signal for BAFETINIB. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hub