Back to targets

Target detail

ACVR1B

activin A receptor type 1B

Data: Live structured evidence (Supabase)

Marker index metadata

Foundation row from public.targets — full Open Targets / ChEMBL preload remains a future operator job (Phase 8H+).

Display name: activin A receptor type 1B

Aliases: ACVR1B, activin A receptor type 1B

Type / organism: protein_coding · Homo sapiens

Source: opentargets · ENSG00000135503

Index freshness: last_synced_at 2026-05-15T17:39:28.372+00:00 · updated 2026-05-15T17:39:28.717718+00:00

Limitations & build flags

  • Read-only structured navigator
  • No clinical outcome benefit inferred
  • Trial presence does not imply success
  • Drug identity may require normalization
  • Terminated/withdrawn trials must remain visible
Target index (foundation)

This symbol is listed in public.targets (operator seed or future preload). Connector-backed sections below may still show empty states until ChEMBL / Open Targets / ClinicalTrials.gov mirror rows exist for this marker.

Live structured evidence · sources

Connectors represented in loaded rows for ACVR1B. Empty groups mean no matching rows — not a claim about biology or clinical use.

  • Open TargetsLive when indexed

    Disease–target evidence rows when operators run enrich:opentargets (GraphQL from trusted scripts only).

  • ChEMBLLive when indexed

    Drug–target and related enrichment rows when operators run enrich:chembl (server/CLI only).

  • CANTI signal builderLive when indexed

    Deterministic repurposing-signal rows produced by the in-repo signal builder when operators run the build pipeline.

Open Targets · disease–target evidence

Rows from disease_target_evidence for this symbol.

glioblastoma

literature · opentargets

ChEMBL · linked drugs (drug_targets)

Drug records tied via drug_targets — mechanistic linkage only.

PD-169316

chembl17331

Open drug

CHEMBL511337

chembl511337

Open drug

CHEMBL1829512

chembl1829512

Open drug

CHEMBL478649

chembl478649

Open drug

PELITINIB

chembl607707

Open drug

TUCATINIB

chembl3989868

Open drug

VX-702

chembl1090090

Open drug

PAXALISIB

chembl3813842

Open drug

AMG-208

chembl496102

Open drug

CHEMBL596380

chembl596380

Open drug

TOVORAFENIB

chembl3348923

Open drug

CHEMBL266325

chembl266325

Open drug

PAZOPANIB

chembl477772

Open drug

AST-487

chembl574738

Open drug

CHEMBL3099673

chembl3099673

Open drug

STAUROSPORINE

chembl388978

Open drug

CHEMBL1363184

chembl1363184

Open drug

CHEMBL516312

chembl516312

Open drug

CHEMBL64758

chembl64758

Open drug

ENCORAFENIB

chembl3301612

Open drug

REGORAFENIB

chembl1946170

Open drug

CHEMBL284861

chembl284861

Open drug

CHEMBL526901

chembl526901

Open drug

A-443654

chembl379300

Open drug

SORAFENIB

chembl1336

Open drug

CHEMBL97771

chembl97771

Open drug

CHEMBL1802727

chembl1802727

Open drug

ANILINOQUINAZOLINE1

chembl382590

Open drug

BMS-754807

chembl575448

Open drug

CHEMBL1233882

chembl1233882

Open drug

CHEMBL3236464

chembl3236464

Open drug

GW632580X

chembl261849

Open drug

CHEMBL595545

chembl595545

Open drug

CHEMBL551623

chembl551623

Open drug

CHEMBL235658

chembl235658

Open drug

VANDETANIB

chembl24828

Open drug

SP-600125

chembl1725279

Open drug

CHEMBL47940

chembl47940

Open drug

CHEMBL562347

chembl562347

Open drug

CRIZOTINIB

chembl601719

Open drug

ANILINOPYRIMIDINE1

chembl383899

Open drug

CHEMBL1964275

chembl1964275

Open drug

CHEMBL607196

chembl607196

Open drug

PACRITINIB

chembl2035187

Open drug

CHEMBL450519

chembl450519

Open drug

CHEMBL1822054

chembl1822054

Open drug

CHELERYTHRINE

chembl13045

Open drug

GALUNISERTIB

chembl2364611

Open drug

ENZASTAURIN

chembl300138

Open drug

AFATINIB

chembl1173655

Open drug

COBIMETINIB

chembl2146883

Open drug

INDIRUBIN-3-MONOXIME

chembl126077

Open drug

XL-019

chembl3545328

Open drug

AZD-4547

chembl3184679

Open drug

CHEMBL3629616

chembl3629616

Open drug

6BIO

chembl409450

Open drug

MK-5108

chembl3600873

Open drug

AZD-8186

chembl3408248

Open drug

HMN-214

chembl3991927

Open drug

TAK-593

chembl2180604

Open drug

TIVOZANIB

chembl1289494

Open drug

CHEMBL551021

chembl551021

Open drug

FOSTAMATINIB

chembl2103830

Open drug

FEDRATINIB

chembl1287853

Open drug

CHEMBL261491

chembl261491

Open drug

PONATINIB

chembl1171837

Open drug

CHEMBL1829505

chembl1829505

Open drug

AG1295

chembl7724

Open drug

CHEMBL1829602

chembl1829602

Open drug

CHEMBL1644616

chembl1644616

Open drug

CHEMBL410456

chembl410456

Open drug

VACTOSERTIB

chembl3260567

Open drug

CHEMBL2017253

chembl2017253

Open drug

CYC-116

chembl482967

Open drug

CHEMBL1186409

chembl1186409

Open drug

DANUSERTIB

chembl402548

Open drug

CHEMBL1987813

chembl1987813

Open drug

CHEMBL1081678

chembl1081678

Open drug

CHEMBL2218936

chembl2218936

Open drug

CHEMBL1828640

chembl1828640

Open drug

PHA-665752

chembl450786

Open drug

CHEMBL1684525

chembl1684525

Open drug

CHEMBL258844

chembl258844

Open drug

PI-103

chembl573339

Open drug

BOHEMINE

chembl83980

Open drug

CHEMBL594371

chembl594371

Open drug

CHEMBL257167

chembl257167

Open drug

CHEMBL65063

chembl65063

Open drug

CHEMBL1802485

chembl1802485

Open drug

CHEMBL2218939

chembl2218939

Open drug

CHEMBL2218930

chembl2218930

Open drug

CHEMBL404939

chembl404939

Open drug

SARACATINIB

chembl217092

Open drug

MK-2206

chembl1079175

Open drug

CHEMBL3818173

chembl3818173

Open drug

CHEMBL328710

chembl328710

Open drug

CHEMBL1331734

chembl1331734

Open drug

LESTAURTINIB

chembl603469

Open drug

SB-202190

chembl278041

Open drug

CHEMBL1684662

chembl1684662

Open drug

CHEMBL1163518

chembl1163518

Open drug

CHEMBL1164180

chembl1164180

Open drug

AMG-900

chembl2140408

Open drug

BOSUTINIB

chembl288441

Open drug

PICTILISIB

chembl521851

Open drug

CHEMBL2030402

chembl2030402

Open drug

DORSOMORPHIN

chembl478629

Open drug

CHEMBL3298678

chembl3298678

Open drug

BX-795

chembl577784

Open drug

NILOTINIB

chembl255863

Open drug

MOTESANIB

chembl572881

Open drug

CHEMBL2425654

chembl2425654

Open drug

ENMD-2076

chembl482968

Open drug

CHEMBL3758502

chembl3758502

Open drug

CHEMBL28324

chembl28324

Open drug

CHEMBL379787

chembl379787

Open drug

CHEMBL573578

chembl573578

Open drug

CHEMBL1164265

chembl1164265

Open drug

AV-412 FREE BASE

chembl2138625

Open drug

CHEMBL3884319

chembl3884319

Open drug

CHEMBL1908395

chembl1908395

Open drug

CHEMBL1241578

chembl1241578

Open drug

CHEMBL1231533

chembl1231533

Open drug

CHEMBL552429

chembl552429

Open drug

SB-220025

chembl274064

Open drug

CHEMBL4084193

chembl4084193

Open drug

CHEMBL1829509

chembl1829509

Open drug

CHEMBL3628627

chembl3628627

Open drug

CHEMBL1164181

chembl1164181

Open drug

SU-11652

chembl13485

Open drug

CHEMBL2425646

chembl2425646

Open drug

HESPERADIN

chembl514409

Open drug

PALBOCICLIB

chembl189963

Open drug

FASCAPLYSIN

chembl602937

Open drug

TG100-115

chembl230011

Open drug

CHEMBL525191

chembl525191

Open drug

LY-294002

chembl98350

Open drug

CHEMBL86755

chembl86755

Open drug

MEISOINDIGO

chembl607535

Open drug

CHEMBL408019

chembl408019

Open drug

CHEMBL473773

chembl473773

Open drug

RUBOXISTAURIN

chembl91829

Open drug

CHEMBL424676

chembl424676

Open drug

GSK-461364

chembl1908394

Open drug

SAR-407899 FREE BASE

chembl1667969

Open drug

OSIMERTINIB

chembl3353410

Open drug

CHEMBL3688339

chembl3688339

Open drug

TEMSIROLIMUS

chembl1201182

Open drug

LINIFANIB

chembl223360

Open drug

CHEMBL120077

chembl120077

Open drug

CHEMBL1829507

chembl1829507

Open drug

PF-04691502

chembl1234354

Open drug

CHEMBL311228

chembl311228

Open drug

CHEMBL1171523

chembl1171523

Open drug

CHEMBL2385596

chembl2385596

Open drug

SU-014813

chembl1721885

Open drug

CHEMBL604483

chembl604483

Open drug

CHEMBL560346

chembl560346

Open drug

CHEMBL104264

chembl104264

Open drug

LENVATINIB

chembl1289601

Open drug

CHEMBL2348862

chembl2348862

Open drug

CHEMBL382799

chembl382799

Open drug

IDELALISIB

chembl2216870

Open drug

CHEMBL2063926

chembl2063926

Open drug

CHEMBL595546

chembl595546

Open drug

CHEMBL1233881

chembl1233881

Open drug

CHEMBL191384

chembl191384

Open drug

CHEMBL1240885

chembl1240885

Open drug

CHEMBL406375

chembl406375

Open drug

CHEMBL3991935

chembl3991935

Open drug

CHEMBL2385579

chembl2385579

Open drug

BRIVANIB

chembl377300

Open drug

CHEMBL3629013

chembl3629013

Open drug

CHEMBL101683

chembl101683

Open drug

CHEMBL1829506

chembl1829506

Open drug

CHEMBL1076555

chembl1076555

Open drug

KW-2449

chembl1908397

Open drug

CHEMBL249097

chembl249097

Open drug

CHEMBL3771285

chembl3771285

Open drug

CHEMBL210618

chembl210618

Open drug

CHEMBL1908396

chembl1908396

Open drug

PF-03814735

chembl4289017

Open drug

CHEMBL599894

chembl599894

Open drug

CHEMBL288064

chembl288064

Open drug

SONOLISIB

chembl411907

Open drug

QUINOXALINE1

chembl259389

Open drug

CHEMBL2402081

chembl2402081

Open drug

CHEMBL1934353

chembl1934353

Open drug

SELUMETINIB

chembl1614701

Open drug

SB-202474

chembl278724

Open drug

CHEMBL471901

chembl471901

Open drug

DEFACTINIB

chembl3137331

Open drug

CHEMBL2218940

chembl2218940

Open drug

CHEMBL155333

chembl155333

Open drug

CHEMBL515466

chembl515466

Open drug

CERITINIB

chembl2403108

Open drug

CHEMBL2376648

chembl2376648

Open drug

CHEMBL2425644

chembl2425644

Open drug

CHEMBL2385591

chembl2385591

Open drug

NMS-1286937

chembl1094408

Open drug
repoDB-style · approved-elsewhere discussion candidates

disease_drug_evidence rows on linked drugs whose evidence_type suggests approved-elsewhere discussion context.

No matching rows

Import repoDB-compatible disease–drug evidence or add structured rows to surface discussion candidates here.

ClinicalTrials.gov · trial-matched options

Mirror rows whose text fields mention this symbol — registry context only.

No matching live evidence found

Populate clinical_trials via the registry enrichment flow; this panel matches the symbol token in titles, conditions, or interventions.

CANTI signal builder · target-linked research signals

Repurposing signal rows for drugs linked to this target via drug_targets.

Repurposing research signal · BAFETINIB · v0.1

Deterministic research signal for BAFETINIB. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

Open signals hub

Repurposing research signal · AT-9283 · v0.1

Deterministic research signal for AT-9283. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

Open signals hub

Repurposing research signal · CHEMBL120077 · v0.1

Deterministic research signal for CHEMBL120077. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

Open signals hub

Repurposing research signal · AST-487 · v0.1

Deterministic research signal for AST-487. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

Open signals hub

Repurposing research signal · BMS-387032 · v0.1

Deterministic research signal for BMS-387032. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

Open signals hub

Repurposing research signal · BOSUTINIB · v0.1

Deterministic research signal for BOSUTINIB. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

Open signals hub

Repurposing research signal · CANERTINIB · v0.1

Deterministic research signal for CANERTINIB. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

Open signals hub

Repurposing research signal · CHEMBL104468 · v0.1

Deterministic research signal for CHEMBL104468. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

Open signals hub

Repurposing research signal · CHEMBL1221601 · v0.1

Deterministic research signal for CHEMBL1221601. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

Open signals hub

Repurposing research signal · ALVOCIDIB · v0.1

Deterministic research signal for ALVOCIDIB. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

Open signals hub
Caution / negative-evidence rows

Structured rows with negative evidence_direction on disease–drug or signal tables.

No negative-direction rows

When structured evidence includes explicit negative direction fields, they surface here for oncology review.

Missing evidence · row counts by source string

No ClinicalTrials.gov mirror rows mention this symbol in titles, conditions, or interventions (within the loaded window).

  • chembl: 491
  • canti_signal_builder: 10
  • opentargets: 1
Summary row (aggregated list)

Structured evidence rows link this marker to cohort contexts when ingested — interpret as research context only.

Disease contexts

0

Linked drugs

0

Linked in dataset

0

Research signals

0

Evidence badges (illustrative)

Doctor-discussion candidate and related tags are descriptive only.

Appears in source landscapeLinked in datasetRequires oncology review
Linked research signals (list read)

Signals list: Live structured evidence (Supabase)

Repurposing research signal · ALVOCIDIB · v0.1

Deterministic research signal for ALVOCIDIB. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

View signals hub

Repurposing research signal · CHEMBL1221601 · v0.1

Deterministic research signal for CHEMBL1221601. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

View signals hub

Repurposing research signal · CHEMBL104468 · v0.1

Deterministic research signal for CHEMBL104468. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

View signals hub

Repurposing research signal · CANERTINIB · v0.1

Deterministic research signal for CANERTINIB. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

View signals hub

Repurposing research signal · BOSUTINIB · v0.1

Deterministic research signal for BOSUTINIB. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

View signals hub

Repurposing research signal · AST-487 · v0.1

Deterministic research signal for AST-487. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

View signals hub

Repurposing research signal · BMS-387032 · v0.1

Deterministic research signal for BMS-387032. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

View signals hub

Repurposing research signal · CHEMBL120077 · v0.1

Deterministic research signal for CHEMBL120077. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

View signals hub

Repurposing research signal · AT-9283 · v0.1

Deterministic research signal for AT-9283. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

View signals hub

Repurposing research signal · BAFETINIB · v0.1

Deterministic research signal for BAFETINIB. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.

View signals hub