Target detail
ACHE
acetylcholinesterase (Yt blood group)
Data: Live structured evidence (Supabase)
Foundation row from public.targets — full Open Targets / ChEMBL preload remains a future operator job (Phase 8H+).
Display name: acetylcholinesterase (Yt blood group)
Aliases: ACHE, acetylcholinesterase (Yt blood group)
Type / organism: protein_coding · Homo sapiens
Source: opentargets · ENSG00000087085
Index freshness: last_synced_at 2026-05-15T18:37:13.566+00:00 · updated 2026-05-15T18:37:14.037966+00:00
Limitations & build flags
- Read-only structured navigator
- No clinical outcome benefit inferred
- Trial presence does not imply success
- Drug identity may require normalization
- Terminated/withdrawn trials must remain visible
This symbol is listed in public.targets (operator seed or future preload). Connector-backed sections below may still show empty states until ChEMBL / Open Targets / ClinicalTrials.gov mirror rows exist for this marker.
Connectors represented in loaded rows for ACHE. Empty groups mean no matching rows — not a claim about biology or clinical use.
- ClinicalTrials.govLive when indexed
Registry mirror rows in clinical_trials when operators run the CT.gov enrichment CLI — browser never calls the registry directly.
- Open TargetsLive when indexed
Disease–target evidence rows when operators run enrich:opentargets (GraphQL from trusted scripts only).
- ChEMBLLive when indexed
Drug–target and related enrichment rows when operators run enrich:chembl (server/CLI only).
- CANTI signal builderLive when indexed
Deterministic repurposing-signal rows produced by the in-repo signal builder when operators run the build pipeline.
Rows from disease_target_evidence for this symbol.
glioblastoma
literature · opentargets
Drug records tied via drug_targets — mechanistic linkage only.
CHEMBL292314
chembl292314
CHEMBL124156
chembl124156
CHEMBL286234
chembl286234
CHEMBL92736
chembl92736
CHEMBL133897
chembl133897
CHEMBL57842
chembl57842
CHEMBL347539
chembl347539
CHEMBL337675
chembl337675
CHEMBL131598
chembl131598
CHEMBL157410
chembl157410
CHEMBL87320
chembl87320
CHEMBL155945
chembl155945
CAPROCTAMINE
chembl11805
CHEMBL348607
chembl348607
CHEMBL134382
chembl134382
TOPOTECAN
chembl84
CHEMBL153865
chembl153865
CHEMBL553803
chembl553803
CHEMBL29300
chembl29300
CHEMBL154972
chembl154972
CHEMBL537266
chembl537266
CHEMBL542467
chembl542467
CHEMBL58252
chembl58252
CHEMBL143055
chembl143055
ISOFLUROPHATE
chembl1025
CHEMBL156763
chembl156763
CHEMBL328102
chembl328102
CHEMBL160219
chembl160219
CHEMBL295017
chembl295017
CHEMBL296429
chembl296429
CHEMBL130270
chembl130270
CHEMBL609668
chembl609668
CHEMBL60074
chembl60074
CHEMBL92775
chembl92775
CHEMBL87280
chembl87280
CHEMBL60180
chembl60180
CHEMBL92460
chembl92460
CHEMBL130628
chembl130628
CHEMBL299435
chembl299435
OBIDOXIME CHLORIDE
chembl291233
CHEMBL133388
chembl133388
RANITIDINE
chembl1790041
CHEMBL126939
chembl126939
CHEMBL132030
chembl132030
CHEMBL58511
chembl58511
CHEMBL311118
chembl311118
CHEMBL1202865
chembl1202865
CHEMBL609671
chembl609671
CHEMBL122983
chembl122983
CHEMBL99581
chembl99581
CHEMBL131320
chembl131320
CHEMBL62664
chembl62664
BENZGALANTAMINE GLUCONATE
chembl6068431
CHEMBL58194
chembl58194
CHEMBL92663
chembl92663
CHEMBL441632
chembl441632
CHEMBL286990
chembl286990
CHEMBL612099
chembl612099
PRALIDOXIME
chembl1420
CHEMBL132133
chembl132133
BROFAROMINE
chembl160347
CHEMBL59074
chembl59074
CHEMBL355740
chembl355740
CHEMBL176521
chembl176521
CHEMBL329531
chembl329531
CHEMBL92463
chembl92463
4-ISOPROPYLPHENSERINE
chembl129837
CHEMBL293751
chembl293751
CHEMBL62210
chembl62210
CHEMBL155863
chembl155863
CHEMBL554472
chembl554472
CHEMBL86233
chembl86233
CHEMBL299898
chembl299898
CHEMBL340854
chembl340854
CHEMBL293268
chembl293268
CHEMBL128894
chembl128894
CHEMBL132619
chembl132619
CHEMBL155768
chembl155768
OCTAAMINOACRIDINE
chembl263198
CHEMBL612100
chembl612100
CHEMBL62031
chembl62031
CHEMBL74089
chembl74089
CHEMBL350464
chembl350464
CHEMBL87373
chembl87373
CHEMBL553187
chembl553187
CHEMBL87937
chembl87937
CHEMBL1202874
chembl1202874
CHEMBL1204162
chembl1204162
CHEMBL336276
chembl336276
CHEMBL287387
chembl287387
CHEMBL555477
chembl555477
CHEMBL555575
chembl555575
CHEMBL92142
chembl92142
CHEMBL89012
chembl89012
CHEMBL131536
chembl131536
CHEMBL1203535
chembl1203535
CHEMBL87980
chembl87980
CHEMBL65356
chembl65356
CHEMBL62084
chembl62084
CHEMBL609150
chembl609150
CHEMBL540833
chembl540833
CHEMBL294251
chembl294251
EDROPHONIUM CHLORIDE
chembl1128
CHEMBL359198
chembl359198
CHEMBL157208
chembl157208
CHEMBL156874
chembl156874
CHEMBL93619
chembl93619
PRALIDOXIME CHLORIDE
chembl748
CHEMBL130112
chembl130112
CHEMBL128172
chembl128172
CHEMBL74257
chembl74257
ACOTIAMIDE HYDROCHLORIDE
chembl2107308
CHEMBL45118
chembl45118
CHEMBL1202885
chembl1202885
CHEMBL41652
chembl41652
CHEMBL131588
chembl131588
CHEMBL341251
chembl341251
CHEMBL157182
chembl157182
CHEMBL77896
chembl77896
CHEMBL130738
chembl130738
CHEMBL93936
chembl93936
CHEMBL419457
chembl419457
EDROPHONIUM BROMIDE
chembl60745
PYRIDOSTIGMINE BROMIDE
chembl812
CHEMBL155746
chembl155746
CHEMBL130427
chembl130427
CHEMBL47375
chembl47375
CHEMBL87550
chembl87550
CHEMBL99655
chembl99655
CHEMBL156931
chembl156931
CHEMBL543779
chembl543779
CHEMBL539115
chembl539115
CHEMBL315515
chembl315515
CHEMBL285891
chembl285891
CHEMBL131286
chembl131286
ETHYLPHENSERINE
chembl340391
CHEMBL419470
chembl419470
CHEMBL445883
chembl445883
CHEMBL80221
chembl80221
CHEMBL1203534
chembl1203534
CHEMBL27675
chembl27675
PROPANIDID
chembl2105345
CHEMBL263322
chembl263322
HUPRINE X
chembl208599
CHEMBL418955
chembl418955
CHEMBL292788
chembl292788
CHEMBL88026
chembl88026
CHEMBL544022
chembl544022
CHEMBL348318
chembl348318
CHEMBL334971
chembl334971
CHEMBL154263
chembl154263
CHEMBL152722
chembl152722
CHEMBL609977
chembl609977
CHEMBL132494
chembl132494
CHEMBL46151
chembl46151
CHEMBL132285
chembl132285
CHEMBL87441
chembl87441
CHEMBL61905
chembl61905
CHEMBL87128
chembl87128
CHEMBL335167
chembl335167
CHEMBL173935
chembl173935
CHEMBL294891
chembl294891
CHEMBL553212
chembl553212
CHEMBL315013
chembl315013
BENEXTRAMINE
chembl19060
CHEMBL309667
chembl309667
CHEMBL418917
chembl418917
CHEMBL340866
chembl340866
CHEMBL293316
chembl293316
CHEMBL442361
chembl442361
CHEMBL134488
chembl134488
CHEMBL544669
chembl544669
CHEMBL1204296
chembl1204296
CHEMBL87295
chembl87295
CHEMBL130666
chembl130666
CHEMBL302179
chembl302179
VELNACRINE
chembl51934
XANTHOSTIGMINE
chembl340427
CHEMBL317162
chembl317162
CHEMBL319541
chembl319541
NEOSTIGMINE METHYLSULFATE
chembl211471
MINAPRINE HYDROCHLORIDE
chembl1364551
CHEMBL174228
chembl174228
CHEMBL314398
chembl314398
CHEMBL66309
chembl66309
CHEMBL160836
chembl160836
CHEMBL61126
chembl61126
CHEMBL65585
chembl65585
CHEMBL59490
chembl59490
CHEMBL14598
chembl14598
CHEMBL309351
chembl309351
CHEMBL76135
chembl76135
CHEMBL93123
chembl93123
CHEMBL65018
chembl65018
CHEMBL314766
chembl314766
CHEMBL431784
chembl431784
CHEMBL92955
chembl92955
CHEMBL75743
chembl75743
CHEMBL294674
chembl294674
CHEMBL87649
chembl87649
disease_drug_evidence rows on linked drugs whose evidence_type suggests approved-elsewhere discussion context.
No matching rows
Import repoDB-compatible disease–drug evidence or add structured rows to surface discussion candidates here.
Mirror rows whose text fields mention this symbol — registry context only.
NCT03332355 — Procaspase Activating Compound-1 (PAC-1) in the Treatment of Advanced Malignancies - Component 2
Status: TERMINATED · clinicaltrials.gov
Open trials hubNCT04743310 — Fluorescence Detection of Adult Primary Central Nervous System Tumors With Tozuleristide and the Canvas System
Status: COMPLETED · clinicaltrials.gov
Open trials hubRepurposing signal rows for drugs linked to this target via drug_targets.
Repurposing research signal · 7-ETHYL-10-HYDROXYCAMPTOTHECIN · v0.1
Deterministic research signal for 7-ETHYL-10-HYDROXYCAMPTOTHECIN. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
Open signals hubRepurposing research signal · CAMPTOTHECIN · v0.1
Deterministic research signal for CAMPTOTHECIN. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
Open signals hubStructured rows with negative evidence_direction on disease–drug or signal tables.
No negative-direction rows
When structured evidence includes explicit negative direction fields, they surface here for oncology review.
- chembl: 462
- canti_signal_builder: 2
- clinicaltrials.gov: 2
- opentargets: 1
Structured evidence rows link this marker to cohort contexts when ingested — interpret as research context only.
Disease contexts
0
Linked drugs
0
Linked in dataset
0
Research signals
0
Doctor-discussion candidate and related tags are descriptive only.
Signals list: Live structured evidence (Supabase)
Repurposing research signal · CAMPTOTHECIN · v0.1
Deterministic research signal for CAMPTOTHECIN. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hubRepurposing research signal · 7-ETHYL-10-HYDROXYCAMPTOTHECIN · v0.1
Deterministic research signal for 7-ETHYL-10-HYDROXYCAMPTOTHECIN. Aggregate template score 55 (not a clinical endpoint). Contributing canonical sources observed in this rollup: chembl, opentargets. No failed-repoDB or terminated-trial penalty lines fired for this rollup. Missing relative to the Phase 8A template: glioma/brain-tumor–scoped ClinicalTrials.gov disease–drug evidence; repoDB-style disease–drug labels. This row requires clinical/research review before any operational use — not care-planning guidance, dose planning, or outcome-benefit claims.
View signals hub