Target detail
ACAT1
acetyl-CoA acetyltransferase 1
Data: Live structured evidence (Supabase)
Foundation row from public.targets — full Open Targets / ChEMBL preload remains a future operator job (Phase 8H+).
Display name: acetyl-CoA acetyltransferase 1
Aliases: ACAT1, acetyl-CoA acetyltransferase 1
Type / organism: protein_coding · Homo sapiens
Source: opentargets · ENSG00000075239
Index freshness: last_synced_at 2026-05-15T18:23:57.642+00:00 · updated 2026-05-15T18:23:58.091703+00:00
Limitations & build flags
- Read-only structured navigator
- No clinical outcome benefit inferred
- Trial presence does not imply success
- Drug identity may require normalization
- Terminated/withdrawn trials must remain visible
This symbol is listed in public.targets (operator seed or future preload). Connector-backed sections below may still show empty states until ChEMBL / Open Targets / ClinicalTrials.gov mirror rows exist for this marker.
Connectors represented in loaded rows for ACAT1. Empty groups mean no matching rows — not a claim about biology or clinical use.
- Open TargetsLive when indexed
Disease–target evidence rows when operators run enrich:opentargets (GraphQL from trusted scripts only).
- ChEMBLLive when indexed
Drug–target and related enrichment rows when operators run enrich:chembl (server/CLI only).
Rows from disease_target_evidence for this symbol.
glioblastoma
literature · opentargets
Drug records tied via drug_targets — mechanistic linkage only.
NEVANIMIBE
chembl46423
CHEMBL3806198
chembl3806198
CL-976
chembl22373
CHEMBL5290636
chembl5290636
CHEMBL3805411
chembl3805411
CHEMBL5653589
chembl5653589
CHEMBL5203276
chembl5203276
BMS-986172
chembl5418882
CHEMBL573970
chembl573970
CHEMBL3806307
chembl3806307
CHEMBL3222262
chembl3222262
CHEMBL3805043
chembl3805043
ELDACIMIBE
chembl2105855
CHEMBL33780
chembl33780
CHEMBL47095
chembl47095
CHEMBL5204128
chembl5204128
EFLUCIMIBE
chembl1908306
HUPERZINE A
chembl395280
CHEMBL5542126
chembl5542126
MITOTANE
chembl1670
TP-020
chembl4455357
HUPERZINE B
chembl245079
LECIMIBIDE
chembl274185
CHEMBL3806116
chembl3806116
CHEMBL5202474
chembl5202474
CHEMBL3805795
chembl3805795
CHEMBL3805648
chembl3805648
CHEMBL5207578
chembl5207578
CHEMBL3805710
chembl3805710
disease_drug_evidence rows on linked drugs whose evidence_type suggests approved-elsewhere discussion context.
No matching rows
Import repoDB-compatible disease–drug evidence or add structured rows to surface discussion candidates here.
Mirror rows whose text fields mention this symbol — registry context only.
No matching live evidence found
Populate clinical_trials via the registry enrichment flow; this panel matches the symbol token in titles, conditions, or interventions.
Repurposing signal rows for drugs linked to this target via drug_targets.
No research signals for linked drugs
Run the deterministic signal builder after drug_targets and source rows are present.
Structured rows with negative evidence_direction on disease–drug or signal tables.
No negative-direction rows
When structured evidence includes explicit negative direction fields, they surface here for oncology review.
No ClinicalTrials.gov mirror rows mention this symbol in titles, conditions, or interventions (within the loaded window).
- chembl: 29
- opentargets: 1
Structured evidence rows link this marker to cohort contexts when ingested — interpret as research context only.
Disease contexts
0
Linked drugs
0
Linked in dataset
0
Research signals
0
Doctor-discussion candidate and related tags are descriptive only.
Signals list: Live structured evidence (Supabase)
No matching live evidence found
When repurposing_signal rows reference this marker via linked drugs, summaries appear here.