Disease hub

Melanoma

Open Targets catalogue label: melanoma

Melanoma-oriented bucket — evidence tables and trial mirrors are keyword-matched conservatively. This hub is for research navigation, not staging or treatment selection.

Also indexed as: cutaneous melanoma · skin melanoma · malignant melanoma · melanoma · EFO_0000756 · Naevocarcinoma · melanoma, malignant · melanoma (disease) · MONDO:0005105 · OMIM:155755 · ONCOTREE:MEL · MESH:D008545 · OMIM:155600 · ICDO:8720/3 · UMLS:C0025202 · MEDGEN:9944 · UMLS:CN971653 · EFO:0000756 · NANDO:2200077 · KEGG:05218 · HP:0002861 · SCTID:372244006 · NCIT:C3224 · DOID:1909 · Orphanet:411533

Data: Live structured evidence (Supabase)

Loaded rows last touched 2026-05-16 (UTC) — connector schedules run server-side; api_sync_log is not on the public read surface.

Open guided lookup (general disease context)

Limitations & build flags

Read-only structured navigator
No clinical outcome benefit inferred
Trial presence does not imply success
Drug identity may require normalization
Terminated/withdrawn trials must remain visible

Disease–target coverage (Phase 8J)

Open Targets associatedTargets.count vs CANTI index — not biological absence when hub panels are empty.

Coverage not probed yet

Ratio unavailable

This bar is intentionally neutral — it does not represent 0% biological evidence. A real probe records Open Targets totals vs indexed rows.

Run npm run probe:disease-targets -- --disease "…" --dry-run then a real probe when ready — see docs/runbooks/gbm-preload.md.

Open Targets universe (Phase 8M.0)

Associated targets (source): 13,182
Count type: Exact (GraphQL count)
Indexed / shown vs universe: 0 indexed live · 0 shown live — 0.0% of source total
Last checked: 2026-05-15 14:18:57 UTC

CANTI has only indexed a subset of the Open Targets association catalogue for this hub. Higher Platform counts do not imply missing clinical care signals.

Expand this disease evidence graph

Ask operators to widen bounded imports (Open Targets slices, registry rows, and ChEMBL target lanes) for read-only browsing here. Requests are rate-limited and reviewed — not medical advice, not care instructions, and not a promise of timing.

Choose a preset depth for the public queue. Wider “full catalog” style runs stay operator-led so public traffic cannot trigger unbounded work.

Full review breadth

Operator approval only — not available as a public button. Use your internal change process if the hub needs a larger, cost-reviewed materialization pass.

Request evidence indexing for this hub

This page may show few structured evidence rows in CANTI compared with what public sources can contain. You can ask operators to queue a bounded evidence refresh for read-only browsing — not medical advice, not treatment guidance, and not a substitute for oncology review.

No prior request found for this disease key in the queue log. Submitting sends a rate-limited operator signal only.

Source-backed evidence · connectors

Requires oncology review — empty groups mean no matching rows in this load window, not a claim about biology or clinical use. Large lists load progressively.

ClinicalTrials.govLive when indexed
Registry mirror rows in clinical_trials when operators run the CT.gov enrichment CLI — browser never calls the registry directly.

Disease–target evidence

Rows from disease_target_evidence bucketed to this hub (0 total).

No matching live evidence found

Ingest Open Targets or other disease–target rows that reference this disease label bucket.

Linked targets (aggregated)

Distinct symbols from disease rows and drug_targets on linked drugs (0 total).

No linked targets

Populate disease–target rows and drug_targets to surface symbols here.

Linked drugs

Drug records referenced by disease–drug or disease–target rows (0 total).

No linked drug rows

When disease_drug_evidence and drugs rows exist for this hub, they are listed here.

Approved-elsewhere discussion candidates

disease_drug_evidence rows whose evidence_type suggests approved-elsewhere discussion context — discussion only.

No matching rows

Import repoDB-compatible disease–drug evidence or add structured rows to surface discussion candidates here.

Trial-matched options

Registry mirror rows matched to this hub (5 total).

NCT02223052 — Bioequivalence & Food Effect Study in Patients With Solid Tumor or Hematologic Malignancies

Status: COMPLETED · Other historical trials · clinicaltrials.gov

Open trials hub

NCT05909618 — Crizanlizumab Alone or in Combination With Nivolumab for Glioblastoma and Melanoma With Brain Metastases

Status: RECRUITING · Open or active trials · clinicaltrials.gov

Open trials hub

NCT01607905 — Safety Study of KPT-330 (Selinexor) in Patients With Advanced or Metastatic Solid Tumor Cancer

Status: COMPLETED · Completed trials with indexed results · clinicaltrials.gov

Open trials hub

NCT02431572 — A Pilot Study to Evaluate PBR PET in Brain Tumor Patients Treated With Chemoradiation or Immunotherapy

Status: COMPLETED · Completed trials with indexed results · clinicaltrials.gov

Open trials hub

NCT01433991 — A Study of E7050 in Combination With E7080 in Participants With Advanced Solid Tumors (Dose Escalation) and in Participants With Recurrent Glioblastoma or Unresectable Stage III or Stage IV Melanoma After Prior Systemic Therapy (Expansion Cohort and Phase 2)

Status: TERMINATED · Stopped or withdrawn trials · clinicaltrials.gov

These rows can provide caution or historical context.

Open trials hub

Deterministic CANTI · Target-linked research signals

drug_repurposing_signals rows with source containing "canti" (0 total).

No CANTI-built signals in window

Run the deterministic signal builder after evidence rows and drug linkage exist.

Caution / negative-evidence

Structured rows with negative evidence_direction (0 total).

No negative-direction rows

When structured evidence includes explicit negative direction fields, they surface here for oncology review.

Missing evidence · source string counts

No disease_target_evidence or disease_drug_evidence rows bucketed to this hub in the current load window — ingestion jobs populate these tables; empty groups are not clinical claims.

clinicaltrials.gov: 5